Enzyme Details

 EC Classification 1.1.1
 Enzyme name
(recommended)
With NAD(+) or NADP(+) as acceptor
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NAD+ + D-Lactate <-> Pyruvate + NADH + H+
NAD+ + Glucose 6-phosphate <-> NADH + H+ + 6-Phospho-D-gluconate
L-Sorbose 1-phosphate <-> D-Sorbitol 6-phosphate
2 NAD+ + H2O + UDPgalactose <-> 2 NADH + 2 H+ + UDP-D-galacturonate
NAD+ + 2-Hydroxybutyrate <-> NADH + H+ + 2-Oxobutyrate
NADP+ + Xylitol <-> H+ + NADPH + D-Xylose
NADP+ + L-Gulonate <-> H+ + NADPH + D-Glucuronate
NADP+ + Testosterone <-> H+ + NADPH + Androst-4-ene-3,17-dione
NADP+ + 3beta-Hydroxyandrost-5-en-17-one <-> H+ + NADPH + Androst-4-ene-3,17-dione
NADP+ + Estradiol-17beta <-> H+ + NADPH + Estrone
NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione
H+ + NADPH + Methylglyoxal <-> NADP+ + Hydroxyacetone
H2O + 2 NADP+ + dTDPglucose <-> 2 H+ + 2 NADPH + dTDP-D-glucuronate
NAD+ + 4-Pyridoxate <-> NADH + H+ + 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
H+ + NADPH + beta-D-Galactose <-> NADP+ + 3-Keto-beta-D-galactose
NADP+ + D-Sorbitol 6-phosphate <-> H+ + NADPH + Sorbose 1-phosphate
NADH + H+ + Butanal <-> NAD+ + 1-Butanol
H+ + NADPH + Butanal <-> NADP+ + 1-Butanol
NADP+ + Indan-1-ol <-> H+ + NADPH + Indanone
NAD+ + (S)-Mandelate <-> NADH + H+ + alpha-Oxo-benzeneacetic acid
NADH + H+ + CO2 + 5-Acetamidopentanoate <-> NAD+ + H2O + 6-Acetamido-2-oxohexanoate
NAD+ + 4-Phospho-D-erythronate <-> NADH + H+ + 2-Oxo-3-hydroxy-4-phosphobutanoate
NADP+ + 1-Alkyl-sn-glycero-3-phosphate <-> H+ + NADPH + O-Alkylglycerone phosphate
NAD+ + 2-Dehydro-3-deoxy-D-arabinonate <-> NADH + H+ + (4S)-5-Hydroxy-2,4-dioxopentanoate
NADH + H+ + 3-Hydroxy-2-methylpyridine-4,5-dicarboxylate <-> NAD+ + H2O + 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
NAD+ + 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA <-> NADH + H+ + 3alpha,7alpha-Dihydroxy-5beta-24-oxocholestanoyl-CoA
NAD+ + 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA <-> NADH + H+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA
NAD+ + Coenzyme A + Ethylene oxide <-> NADH + H+ + Acetyl-CoA
NAD+ + 6-Hydroxycyclohex-1-enecarbonyl-CoA <-> NADH + H+ + 6-Ketoxycyclohex-1-ene-1-carboxyl-CoA
NAD+ + 2-Hydroxycyclohexane-1-carboxyl-CoA <-> NADH + H+ + 2-Ketocyclohexane-1-carboxyl-CoA
NAD+ + L-Idonate <-> NADH + H+ + 5-Dehydro-D-gluconate
H+ + NADPH + 4-Carboxybenzaldehyde <-> NADP+ + 4-Carboxybenzyl alcohol
H+ + NADPH + S-1360 <-> NADP+ + HP1
NADP+ + Acenaphthen-1-ol <-> H+ + NADPH + 1-Acenaphthenone
H+ + NADPH + Benzaldehyde <-> NADP+ + Benzyl alcohol
NADP+ + Benzene dihydrodiol <-> H+ + NADPH + Catechol
H+ + NADPH + D-Erythrose <-> NADP+ + Erythritol
H+ + NADPH + Glyceraldehyde <-> NADP+ + Glycerol
H+ + NADPH + D-Ribose <-> NADP+ + Ribitol
H+ + NADPH + m-Nitrobenzaldehyde <-> NADP+ + m-Nitrobenzyl alcohol
H+ + NADPH + o-Nitrobenzaldehyde <-> NADP+ + o-Nitrobenzyl alcohol
H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol
H+ + NADPH + Pyridine-3-aldehyde <-> NADP+ + 3-Pyridinemethanol
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 3beta-Androstanediol
H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol
NAD+ + 3alpha-Hydroxy-5alpha-pregnan-20-one <-> NADH + H+ + 5alpha-Pregnane-3,20-dione
H+ + NADPH + Phenylglyoxal <-> Unknown + NADP+
NAD+ + 3beta-Hydroxyandrost-5-en-17-one <-> NADH + H+ + Androst-5-ene-3,17-dione
H+ + NADPH + 4-Nitroacetophenone <-> NADP+ + 1-(4-Nitrophenyl)ethanol
NADH + H+ + 5alpha-Androstane-17beta-ol-3-one <-> NAD+ + 5alpha-Androstane-3alpha,17beta-diol
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol
NADH + H+ + Cyclohex-2-enone <-> NAD+ + Cyclohex-2-en-1-ol
NADP+ + Cyclohex-2-en-1-ol <-> H+ + NADPH + Cyclohex-2-enone
H+ + NADPH + Dimethylglyoxal <-> NADP+ + Acetoin
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstan-3beta,17beta-diol
H+ + NADPH + 4-Benzoylpyridine <-> Unknown + NADP+
H+ + NADPH + 2-Oxobutyrate <-> NADP+ + D-2-Hydroxybutyrate
Pyruvate + H+ + NADPH <-> NADP+ + D-Lactate
H+ + NADPH + 4-Methyl-2-oxopentanoate <-> NADP+ + D-2-Hydroxyisocaproate
H+ + NADPH + 2-Oxopentanoate <-> NADP+ + D-2-Hydroxyvalerate
H+ + NADPH + alpha-Ketovaline <-> NADP+ + D-2-Hydroxyisovalerate
H+ + NADPH + 2-Oxohexanoate <-> NADP+ + D-2-Hydroxycaproate
H+ + NADPH + Menadione <-> NADP+ + Menadiol
H+ + NADPH + Succinate semialdehyde <-> NADP+ + 4-Hydroxybutanoate
H+ + NADPH + Testosterone <-> NADP+ + 5beta-Androstane-17beta-ol-3-one
H+ + NADPH + 2-Carboxybenzaldehyde <-> NADP+ + 2-(Hydroxymethyl)benzoic acid
H+ + NADPH + Pyridine-4-aldehyde <-> NADP+ + 4-Pyridinemethanol
NADPH + 5alpha-Dihydrotestosterone-17beta-glucuronide <-> NADP+ + 5alpha-Androstane-3beta-hydroxy,17beta-glucuronide
NADPH + 5alpha-Dihydrotestosterone-17beta-glucuronide <-> NADP+ + 5alpha-Androstane-3alpha-hydroxy,17beta-glucuronide
NADPH + 5alpha-Dihydrotestosterone-17beta-sulfate <-> NADP+ + 5alpha-Androstan-3beta-hydroxy-17beta-sulfate
NADPH + 5alpha-Dihydrotestosterone-17beta-sulfate <-> NADP+ + 5alpha-Androstan-3alpha-hydroxy-17beta-sulfate
NADPH + Tibolone <-> NADP+ + 3beta-Hydroxytibolone
NADPH + Tibolone <-> NADP+ + 3alpha-Hydroxytibolone
NADPH + Tibolone-beta17-sulphate <-> NADP+ + 3beta-Hydroxytibolone-beta17-sulphate
NAD+ + Isopyridoxal <-> NADH + H+ + 5-Pyridoxolactone
NADP+ + 5alpha-Androstane-17beta-ol-3-one <-> H+ + NADPH + Testosterone
H+ + NADPH + 5alpha-Androstane-3alpha-ol-17-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol
H+ + NADPH + Epiandrosterone <-> Unknown + NADP+
H+ + NADPH + Estrone 3-sulfate <-> Unknown + NADP+
H+ + NADPH + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol
H+ + NADPH + Androst-4-ene-3,17-dione <-> NADP+ + Epitestosterone
2 H+ + 2 NADPH + 1,4-Naphthoquinone <-> 2 NADP+ + Hydronaphthoquinone
H+ + NADPH + 1,4-Benzoquinone <-> NADP+ + Hydroquinone
H+ + NADPH + 1,2-Naphthoquinone <-> NADP+ + Naphthalene-1,2-diol
2 H+ + 2 NADPH + 5-Hydroxy-1,4-naphthoquinone <-> 2 NADP+ + 5-Hydroxy-hydronaphthoquinone
NADPH + Methyl-1,4-benzoquinone <-> NADP+ + Methylhydroquinone
2 H+ + 2 NADPH + 2-Methyl-5-hydroxy-1,4-naphthoquinone <-> 2 NADP+ + 2-Methyl-5-hydroxy-hydronaphthoquinone
NADPH + 2,3-Dimethoxy-5-methyl-1,4-benzoquinone <-> NADP+ + 2,3-Dimethoxy-5-methyl-hydroquinone
NADP+ + 20alpha-Hydroxy-4-pregnen-3-one <-> H+ + NADPH + Progesterone
NADH + H+ + 2-Oxohexanoate <-> NAD+ + 2-Hydroxyhexanoate
NADH + H+ + 4-Methyl-2-oxopentanoate <-> NAD+ + 2-Hydroxyisocaproate
NAD+ + Phenyllactate <-> NADH + H+ + Phenylpyruvate
NADH + H+ + alpha-Oxo-benzeneacetic acid <-> NAD+ + Mandelate
NADH + H+ + Keto-tert-leucine <-> NAD+ + 2-Hydroxy-3,3-dimethylbutanoate
NAD+ + L-Lactate <-> Pyruvate + NADH + H+
NADH + H+ + 2-Oxohexanoate <-> NAD+ + 2-Hydroxycaproate
NADH + H+ + 2-Oxopentanoate <-> NAD+ + 2-Hydroxyvalerate
NADH + H+ + alpha-Ketovaline <-> NAD+ + 2-Hydroxyisovalerate
NADH + H+ + 4-Methyl-2-oxopentanoate <-> NAD+ + D-2-Hydroxyisocaproate
NADH + H+ + Methylglyoxal <-> NAD+ + Hydroxyacetone
NADH + H+ + Glyceraldehyde <-> NAD+ + Glycerol
H+ + NADPH + Isatin <-> NADP+ + 2,3-Dihydroxyindole
NADH + H+ + Isatin <-> NAD+ + 2,3-Dihydroxyindole
H+ + NADPH + 5alpha-Androstane-3alpha-ol-17-one <-> NADP+ + 5alpha-Androstane-3alpha,17alpha-diol
H+ + NADPH + 3beta-Hydroxyandrost-5-en-17-one <-> NADP+ + 5-Androstene-3beta,17alpha-diol
NADP+ + Estradiol-17alpha <-> H+ + NADPH + Estrone
NADP+ + Estradiol-17alpha 3-D-glucuronoside <-> H+ + NADPH + Estrone glucuronide
H+ + NADPH + 1-Phenyl-1,2-propanedione <-> Unknown + NADP+
H+ + NADPH + 2,3-Heptanedione <-> Unknown + NADP+
H+ + NADPH + 3,4-Hexanedione <-> NADP+ + Propioin
NADP+ + R-(+)-1-Phenylethanol <-> H+ + NADPH + Acetophenone
NAD+ + R-(+)-1-Phenylethanol <-> NADH + H+ + Acetophenone
NAD+ + Hexanoyl-CoA <-> NADH + H+ + trans-Hex-2-enoyl-CoA
NAD+ + Decanoyl-CoA <-> NADH + H+ + trans-Dec-2-enoyl-CoA
NADH + H+ + 9,10-Phenanthroquinone <-> NAD+ + Phenanthrene-9,10-diol
NAD+ + 2-Dehydro-3-deoxy-L-fuconate <-> NADH + H+ + 2,4-Didehydro-3-deoxy-L-fuconate
NAD+ + 2-Dehydro-3-deoxy-D-xylonate <-> NADH + H+ + (4S)-5-Hydroxy-2,4-dioxopentanoate
NAD+ + 2-Dehydro-3-deoxy-L-fuconate <-> NADH + H+ + 2 L-Lactate
NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione
NADP+ + 5alpha-Androstane-17beta-ol-3-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione
NAD+ + Xylitol 5-phosphate <-> NADH + H+ + D-Xylulose 5-phosphate
NADH + H+ + N-Carbobenzoxy-6-amino-2-oxohexanoic acid <-> NAD+ + N-Carbobenzoxy-L-oxylysine
H+ + PEG-NADH + N-Carbobenzoxy-6-amino-2-oxohexanoic acid <-> NAD+ + N-Carbobenzoxy-L-oxylysine
NAD+ + 2-Dehydro-3-deoxy-L-gluconate <-> NADH + H+ + 2,4-Didehydro-3-deoxy-L-gluconate
NAD+ + 2-Dehydro-3-deoxy-D-arabinonate <-> NADH + H+ + 2,4-Didehydro-3-deoxy-D-arabinonate
NADH + H+ + FAD <-> NAD+ + FADH2
NADH + H+ + 2,6-Dichloroindophenol <-> NAD+ + Reduced 2,6-dichlorophenolindophenol
NADH + H+ + Potassium ferricyanide <-> NAD+ + Reduced potassium ferricyanide
NADH + H+ + Cytochrome c <-> NAD+ + Reduced cytochrome c
NADP+ + 1,2,3,4-Tetrahydronaphth-1-ol <-> H+ + NADPH + alpha-Tetralone
H+ + NADPH + FAD <-> NADP+ + FADH2
NAD+ + Corticosterone <-> NADH + H+ + 11-Dehydrocorticosterone
NAD+ + Cortisol <-> NADH + H+ + Cortisone
NADH + H+ + Nitroblue tetrazolium <-> NAD+ + Reduced nitroblue tetrazolium
2 NADH + 2 H+ + O2 <-> 2 NAD+ + 2 H2O
NAD+ + 5alpha-Androstane-3beta-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione
NAD+ + 5alpha-Pregnane-3alpha-ol-20-one <-> NADH + H+ + 5alpha-Pregnane-3beta-ol-20-one
H+ + NADPH + 3-Methylcyclohexanone <-> NADP+ + 3-Methylcyclohexanol
NADH + H+ + 3-Methylcyclohexanone <-> NAD+ + 3-Methylcyclohexanol
H+ + NADPH + 4-Methylcyclohexanone <-> NADP+ + 4-Methylcyclohexanol
NADH + H+ + 4-Methylcyclohexanone <-> NAD+ + 4-Methylcyclohexanol
NADP+ + Nerol <-> H+ + NADPH + cis-Citral
NAD+ + Nerol <-> NADH + H+ + cis-Citral
H+ + NADPH + Citronellal <-> NADP+ + Citronellol
NADH + H+ + Citronellal <-> NAD+ + Citronellol
H+ + NADPH + 1-Pentanal <-> NADP+ + 1-Pentanol
NAD+ + 1-Pentanol <-> NADH + H+ + 1-Pentanal
H+ + NADPH + 2,4-Dimethyl-3-pentanone <-> NADP+ + 2,4-Dimethyl-3-pentanol
NADH + H+ + 2,4-Dimethyl-3-pentanone <-> NAD+ + 2,4-Dimethyl-3-pentanol
NADP+ + (-)-Menthol <-> H+ + NADPH + (-)-Menthone
NADP+ + (+)-Neomenthol <-> H+ + NADPH + (-)-Menthone
NADP+ + (-)-trans-Carveol <-> H+ + NADPH + (-)-Carvone
H+ + NADPH + (-)-alpha-Thujone <-> NADP+ + (-)-Thujol
H+ + NADPH + (-)-Fenchone <-> NADP+ + (+)-beta-Fenchol
H+ + NADPH + (+)-Camphor <-> NADP+ + (+)-Borneol
NADP+ + (-)-Borneol <-> H+ + NADPH + (-)-Camphor
NADH + H+ + 1,4-Cyclohexanedione <-> NAD+ + 1,4-Cyclohexanediol
H+ + NADPH + Adriamycin <-> NADP+ + Doxorubicinol
H+ + NADPH + L-Xylo-3-hexulose <-> NADP+ + D-Sorbitol
NADP+ + Xylitol <-> H+ + NADPH + L-Xylulose
H+ + NADPH + D-Ribulose <-> NADP+ + Ribitol
H+ + NADPH + Phenylglyoxal <-> NADP+ + 2-Hydroxyacetophenone
H+ + NADPH + 17alpha-Hydroxyprogesterone <-> NADP+ + Androst-4-ene-3,17-dione
H+ + NADPH + 3-Dehydroecdysone <-> NADP+ + Ecdysone
NADP+ + L-Arabitol <-> H+ + NADPH + L-Arabinose
H+ + NADPH + D-Galactose <-> NADP+ + Galactitol
H+ + NADPH + D-Glucose <-> NADP+ + D-Sorbitol
NADH + H+ + D-Xylose <-> NAD+ + Xylitol
H+ + NADPH + Prostaglandin H2 <-> NADP+ + Prostaglandin F2alpha
H+ + NADPH + Glyoxal <-> NADP+ + Glycolaldehyde
H+ + NADPH + 5alpha-Androstan-3alpha-ol-17-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol
H+ + NADPH + 5alpha-Androstane-3beta-ol-17-one <-> NADP+ + 3beta-Androstanediol
H+ + NADPH + 3-Fluorobenzaldehyde <-> NADP+ + 3-Fluorobenzyl alcohol
H+ + NADPH + Cinnamaldehyde <-> NADP+ + Cinnamyl alcohol
NADP+ + 3-Hydroxybenzyl alcohol <-> H+ + NADPH + 3-Hydroxybenzaldehyde
H+ + NADPH + Isopropylbenzaldehyde <-> NADP+ + 2-Isopropylbenzyl alcohol
H+ + NADPH + Erythrose <-> NADP+ + Erythritol
H+ + NADPH + Xylose <-> NADP+ + Xylitol
H+ + NADPH + Arabinose <-> NADP+ + Arabitol
H+ + NADPH + Glucose <-> NADP+ + Sorbitol
H+ + NADPH + Galactose <-> NADP+ + Galactitol
NADP+ + trans-2-Hexenol <-> H+ + NADPH + trans-2-Hexenal
H+ + NADPH + 4-Hydroxy-2-nonenal <-> NADP+ + 4-Hydroxynonenol
H+ + NADPH + Malondialdehyde <-> NADP+ + 3-Hydroxypropanal
H+ + NADPH + Decanal <-> NADP+ + 1-Decanol
H+ + NADPH + Salicylaldehyde <-> NADP+ + Salicyl alcohol
NADPH + AKR4C8 <-> Enzyme-ligand complex
NADP+ + AKR4C8 <-> Enzyme-ligand complex
NADH + AKR4C8 <-> Enzyme-ligand complex
NAD+ + AKR4C8 <-> Enzyme-ligand complex
NADPH + AKR4C9 <-> Enzyme-ligand complex
NADP+ + AKR4C9 <-> Enzyme-ligand complex
NADH + AKR4C9 <-> Enzyme-ligand complex
NAD+ + AKR4C9 <-> Enzyme-ligand complex
H+ + NADPH + D-Xylulose <-> NADP+ + Xylitol
 External links Expasy
KEGG
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IntEnz (EBI)
IUBMB
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