Enzyme Details

 EC Classification 1.1.1.146
 Enzyme name
(recommended)
11beta-hydroxysteroid dehydrogenase
 Alternative names 11beta-hydroxysteroid:NADP+ 11-oxidoreductase
corticosteroid 11beta-dehydrogenase
beta-hydroxysteroid dehydrogenase
11beta-hydroxy steroid dehydrogenase
corticosteroid 11-reductase
dehydrogenase, 11beta-hydroxy steroid
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NAD+ + Cortisol <-> NADH + H+ + Cortisone
NADP+ + Cortisol <-> H+ + NADPH + Cortisone
NADP+ + 11beta-Hydroxysteroid <-> H+ + NADPH + 11-Oxosteroid
NAD+ + Corticosterone <-> NADH + H+ + 11-Dehydrocorticosterone
NADP+ + Corticosterone <-> H+ + NADPH + 11-Dehydrocorticosterone
NAD+ + 11beta-Hydroxyandrost-4-ene-3,17-dione <-> NADH + H+ + Adrenosterone
NADP+ + 11beta-Hydroxyandrost-4-ene-3,17-dione <-> H+ + NADPH + Adrenosterone
NAD+ + Tetrahydrocorticosterone <-> NADH + H+ + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione
NADP+ + Tetrahydrocorticosterone <-> H+ + NADPH + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione
NADP+ + 7alpha-Hydroxycholesterol <-> H+ + NADPH + 7-Ketocholesterol
H+ + NADPH + 7-Ketocholesterol <-> NADP+ + 7-Hydroxycholesterol
NADP+ + 7beta-Hydroxycholesterol <-> H+ + NADPH + 7-Ketocholesterol
NADP+ + Cholesterol <-> H+ + NADPH + 5-Cholesten-3-one
H+ + NADPH + 3-Oxo-5beta-cholanate <-> NADP+ + 3alpha-Hydroxy-5beta-cholanate
NADP+ + Chenodeoxycholate <-> H+ + NADPH + 3alpha-Hydroxy-7-oxo-5beta-cholanate
NADP+ + 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate <-> Unknown + H+ + NADPH
NADP+ + 11-Dehydrocorticosterone <-> Unknown + H+ + NADPH
NADP+ + 3beta-Hydroxyandrost-5-en-17-one <-> H+ + NADPH + Androst-5-ene-3,17-dione
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.1.1.146



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