Enzyme Details

 EC Classification 1.1.1.149
 Enzyme name
(recommended)
20alpha-hydroxysteroid dehydrogenase
 Alternative names 20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase
20alpha-hydroxy steroid dehydrogenase
20alpha-hydroxy steroid dehydrogenase
20alpha-HSD
20alpha-HSDH
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NADP+ + Glycerol <-> H+ + NADPH + D-Glyceraldehyde
NAD+ + 20alpha-Hydroxy-4-pregnen-3-one <-> NADH + H+ + Progesterone
NADP+ + 20alpha-Hydroxy-4-pregnen-3-one <-> H+ + NADPH + Progesterone
NAD+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one <-> NADH + H+ + 17alpha-Hydroxyprogesterone
NADP+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one <-> H+ + NADPH + 17alpha-Hydroxyprogesterone
H+ + NADPH + Pyridine-3-aldehyde <-> NADP+ + 3-Pyridinemethanol
H+ + NADPH + Phenylglyoxal <-> Unknown + NADP+
H+ + NADPH + Ethyl 3-oxobutanoate <-> NADP+ + Ethyl 3-hydroxybutanoate
H+ + NADPH + Cyclohexan-1,2-dione <-> NADP+ + 2-Hydroxycyclohexanone
NADP+ + 5alpha-Pregnan-3alpha,20alpha-diol <-> H+ + NADPH + 3alpha-Hydroxy-5alpha-pregnan-20-one
H+ + NADPH + Corticosterone <-> NADP+ + 11beta,20alpha,21-Trihydroxy-4-pregnene-3-one
H+ + NADPH + Camphorquinone <-> Unknown + NADP+
H+ + NADPH + Cortisone <-> NADP+ + 11beta,17alpha,20alpha,21-Tetrahydroxy-4-pregnene-3-one
H+ + NADPH + 2,4-Pentanedione <-> NADP+ + 4-Hydroxypentan-2-one
NADP+ + Benzene dihydrodiol <-> H+ + NADPH + 2-Hydroxycyclohexa-3,5-diene-1-one
H+ + NADPH + 5beta-Pregnane-3,20-dione <-> NADP+ + 20alpha-Hydroxy-5beta-pregnan-3-one
H+ + NADPH + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NADP+ + 17alpha,20alpha,21-Trihydroxy-5beta-pregnane-3,11-dione
H+ + NADPH + 17alpha-Hydroxypregnenolone <-> NADP+ + 3beta,17alpha-Dihydroxypregn-5-en-20-ol
NADP+ + Pregnanediol <-> H+ + NADPH + 3alpha-Hydroxy-5beta-pregnane-20-one
H+ + NADPH + 17alpha,21-Dihydroxy-5beta-pregnane-3,20-dione <-> NADP+ + 17alpha,20alpha,21-Trihydroxy-5beta-pregnane-3-one
H+ + NADPH + Pregnenolone <-> NADP+ + 3beta-Hydroxypregn-5-en-20-ol
H+ + NADPH + Isatin <-> NADP+ + 2,3-Dihydroxyindole
H+ + NADPH + 3beta-Hydroxy-5beta-pregnane-20-one <-> NADP+ + 5beta-Pregnan-3beta,20alpha-diol
H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol
NADP+ + 1,2,3,4-Tetrahydronaphth-1-ol <-> H+ + NADPH + alpha-Tetralone
NADP+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.1.1.149



© HITS gGmbH