Enzyme Details

 EC Classification 1.1.1.184
 Enzyme name
(recommended)
carbonyl reductase (NADPH)
 Alternative names secondary-alcohol:NADP+ oxidoreductase
aldehyde reductase 1
prostaglandin 9-ketoreductase
xenobiotic ketone reductase
NADPH-dependent carbonyl reductase
ALR3
carbonyl reductase
nonspecific NADPH-dependent carbonyl reductase
carbonyl reductase (NADPH2)
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
Ethanol + NADP+ <-> H+ + NADPH + Acetaldehyde
NAD+ + Ethanol <-> NADH + H+ + Acetaldehyde
H+ + NADPH + Acetone <-> NADP+ + 2-Propanol
NADP+ + Testosterone <-> H+ + NADPH + Androst-4-ene-3,17-dione
NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione
NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione
H+ + NADPH + Testosterone <-> NADP+ + 4-Androstenediol
NADP+ + Prostaglandin F2alpha <-> H+ + NADPH + Prostaglandin E2
NADP+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one <-> H+ + NADPH + 17alpha-Hydroxyprogesterone
NADP+ + R-CHOH-R' <-> H+ + NADPH + R-CO-R'
NAD+ + Indan-1-ol <-> NADH + H+ + Indanone
NADP+ + Indan-1-ol <-> H+ + NADPH + Indanone
NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione
NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> H+ + NADPH + 5beta-Androstane-3,17-dione
H+ + NADPH + 4-Oxonon-2-enal <-> NADP+ + 1-Hydroxynon-2-en-4-one
H+ + NADPH + 4-Oxonon-2-enal <-> NADP+ + 4-Hydroxy-2-nonenal
H+ + NADPH + 4-Oxonon-2-enal <-> NADP+ + 4-Oxononanal
H+ + NADPH + Glutathione-4-Oxonon-2-enal <-> NADP+ + Glutathione-1-Hydroxynon-2-en-4-one
H+ + NADPH + Glutathione-4-Oxonon-2-enal <-> NADP+ + Glutathione-4-Hydroxynon-2-enal
H+ + NADPH + Glutathione-4-Oxonon-2-enal <-> NADP+ + Glutathione-4-Oxononanal
H+ + NADPH + Glyceraldehyde <-> NADP+ + Glycerol
H+ + NADPH + m-Nitrobenzaldehyde <-> NADP+ + m-Nitrobenzyl alcohol
H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol
H+ + NADPH + Propanal <-> NADP+ + 1-Propanol
H+ + NADPH + Pyridine-3-aldehyde <-> NADP+ + 3-Pyridinemethanol
ATP + L-Glutamate + L-Allylglycine <-> ADP + Phosphate + L-gamma-Glutamyl-L-allylglycine
NAD+ + Chloral hydrate <-> NADH + H+ + Trichloroacetate
H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol
H+ + NADPH + Phenylglyoxal <-> Unknown + NADP+
NADP+ + (R)-Indan-1-ol <-> H+ + NADPH + Indanone
NADP+ + (S)-Indan-1-ol <-> H+ + NADPH + Indanone
NAD+ + (S)-2-Butanol <-> NADH + H+ + 2-Butanone
NADH + H+ + 2-Butanone <-> NAD+ + 2-Butanol
NADP+ + (S)-2-Butanol <-> H+ + NADPH + 2-Butanone
H+ + NADPH + 2-Butanone <-> NADP+ + 2-Butanol
H+ + NADPH + 4-Nitroacetophenone <-> NADP+ + 1-(4-Nitrophenyl)ethanol
NADH + H+ + 5alpha-Androstane-17beta-ol-3-one <-> NAD+ + 5alpha-Androstane-3alpha,17beta-diol
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol
H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol
NADH + H+ + 5beta-Androstane-17beta-ol-3-one <-> NAD+ + 5beta-Androstane-3alpha,17beta-diol
NADH + H+ + Acetone <-> NAD+ + 2-Propanol
NADH + H+ + Cyclohex-2-enone <-> NAD+ + Cyclohex-2-en-1-ol
NADP+ + Cyclohex-2-en-1-ol <-> H+ + NADPH + Cyclohex-2-enone
H+ + NADPH + Cyclohex-2-enone <-> NADP+ + Cyclohex-2-en-3-ol
H+ + NADPH + Cyclohexanone <-> NADP+ + Cyclohexanol
NAD+ + (R)-Indan-1-ol <-> NADH + H+ + Indanone
NAD+ + (S)-Indan-1-ol <-> NADH + H+ + Indanone
H+ + NADPH + Dimethylglyoxal <-> NADP+ + Acetoin
NADH + H+ + Pyridine-3-aldehyde <-> NAD+ + 3-Pyridinemethanol
NADH + H+ + Pyridine-4-aldehyde <-> NAD+ + 4-Pyridinemethanol
NADP+ + Chloral hydrate <-> H+ + NADPH + Trichloroacetate
H+ + NADPH + Ethyl 3-methyl-2-oxobutanoate <-> NADP+ + Ethyl 3-methyl-2-hydroxybutanoate
H+ + NADPH + Ketopantoyl lactone <-> Unknown + NADP+
H+ + NADPH + Ethyl 4-chloro-3-oxobutanoate <-> NADP+ + (S)-Ethyl 4-chloro-3-hydroxybutanoate
H+ + NADPH + Ethyl 2-oxobutanoate <-> NADP+ + Ethyl 2-hydroxybutanoate
H+ + NADPH + 2,3-Pentanedione <-> Unknown + NADP+
H+ + NADPH + Methyl 4-chloro-3-oxobutanoate <-> NADP+ + Methyl 4-chloro-3-hydroxybutanoate
H+ + NADPH + Ethyl 2-chloro-3-oxobutanoate <-> NADP+ + Ethyl 2-chloro-3-hydroxybutanoate
H+ + NADPH + Methyl 2-chloro-3-oxobutanoate <-> NADP+ + Methyl 2-chloro-3-hydroxybutanoate
H+ + NADPH + Ethyl pyruvate <-> Unknown + NADP+
H+ + NADPH + 2-Nitrobenzaldehyde <-> NADP+ + 2-Nitrobenzyl alcohol
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstan-3beta,17beta-diol
H+ + NADPH + Daunorubicin <-> Unknown + NADP+
H+ + NADPH + 4-Benzoylpyridine <-> Unknown + NADP+
NAD+ + Cyclohexanol <-> NADH + H+ + Cyclohexanone
H+ + NADPH + Menadione <-> NADP+ + Menadiol
NADH + Methyl-1,4-benzoquinone <-> NAD+ + Methylhydroquinone
NADPH + Methyl-1,4-benzoquinone <-> NADP+ + Methylhydroquinone
NADPH + Crotonaldehyde <-> NADP+ + 2-Buten-1-ol
NADH + Crotonaldehyde <-> NAD+ + 2-Buten-1-ol
NADH + Benzalacetone <-> Unknown + NAD+
NADPH + Benzalacetone <-> Unknown + NADP+
NADH + 4-Benzoylpyridine <-> Unknown + NAD+
NADH + H+ + Menadione <-> NAD+ + Menadiol
NADH + H+ + 4-Nitroacetophenone <-> NAD+ + 1-(4-Nitrophenyl)ethanol
H+ + NADPH + Nonanal <-> NADP+ + 1-Nonanol
H+ + NADPH + 1-Octanal <-> NADP+ + 1-Octanol
H+ + NADPH + Pyridine-4-aldehyde <-> NADP+ + 4-Pyridinemethanol
H+ + NADPH + Ubiquinone-1 <-> NADP+ + Ubiquinol
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + Androstanediol
NADP+ + Prostaglandin B1 <-> Unknown + H+ + NADPH
H+ + NADPH + 3-Benzoylpyridine <-> Unknown + NADP+
H+ + NADPH + Adamantanone <-> NADP+ + Adamantanol
H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + 5beta-Androstane-3beta,17beta-diol
H+ + NADPH + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol
H+ + NADPH + 5alpha-Androstane-3,17-dione <-> NADP+ + 5alpha-Androstane-3beta-ol-17-one
H+ + NADPH + 5beta-Androstane-3,17-dione <-> NADP+ + 5beta-Androstane-3beta-ol-17-one
NADP+ + NADP+ + 5beta-Androstane-17beta-ol-3-one + 5beta-Androstane-17beta-ol-3-one <-> H+ + H+ + NADPH + NADPH + 5beta-Androstane-3,17-dione + 5beta-Androstane-3,17-dione
H+ + NADPH + S-Nitrosoglutathione <-> NADP+ + GSN
H+ + NADPH + 4-Benzoylpyridine <-> NADP+ + Phenyl(pyridin-4-yl)methanol
H+ + NADPH + Adriamycin <-> NADP+ + Doxorubicinol
H+ + NADPH + Daunorubicin <-> NADP+ + 13-Dihydrodaunorubicin
H+ + NADPH + (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate <-> Unknown + NADP+
H+ + NADPH + Isatin <-> NADP+ + 2,3-Dihydroxyindole
H+ + NADPH + 2,3-Hexanedione <-> NADP+ + 3-Hydroxyhexan-2-one
H+ + NADPH + 3,4-Hexanedione <-> NADP+ + Propioin
H+ + NADPH + 2,3-Heptanedione <-> NADP+ + 3-Hydroxyheptan-2-one
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


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