Enzyme Details

 EC Classification 1.1.1.2
 Enzyme name
(recommended)
alcohol dehydrogenase (NADP+)
 Alternative names alcohol:NADP+ oxidoreductase
aldehyde reductase (NADPH2)
NADP-alcohol dehydrogenase
NADP+-aldehyde reductase
NADP+-dependent aldehyde reductase
NADPH-aldehyde reductase
NADPH-dependent aldehyde reductase
nonspecific succinic semialdehyde reductase
ALR 1
low-Km aldehyde reductase
high-Km aldehyde reductase
alcohol dehydrogenase (NADP)
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
Ethanol + NADP+ <-> H+ + NADPH + Acetaldehyde
NADP+ + Primary alcohol <-> H+ + NADPH + Aldehyde
NADP+ + Glycerol <-> H+ + NADPH + D-Glyceraldehyde
NADP+ + 6-Hydroxyhexanoate <-> H+ + NADPH + 6-Oxohexanoate
NADP+ + trans-1,2-Dihydrobenzene-1,2-diol <-> H+ + NADPH + Catechol
NAD+ + Glycerol <-> NADH + H+ + D-Glyceraldehyde
NADP+ + Glycerol <-> H+ + NADPH + Dihydroxyacetone
H+ + NADPH + D-Galactose <-> NADP+ + Galactitol
NADP+ + Xylitol <-> H+ + NADPH + D-Xylose
NADP+ + L-Gulonate <-> H+ + NADPH + D-Glucuronate
NAD+ + 4-Hydroxybutanoate <-> NADH + H+ + Succinate semialdehyde
NADP+ + L-Arabitol <-> H+ + NADPH + L-Arabinose
NADP+ + D-Sorbitol <-> H+ + NADPH + alpha-D-Glucose
NADP+ + Testosterone <-> H+ + NADPH + Androst-4-ene-3,17-dione
NADP+ + (R)-Mevalonate <-> H+ + NADPH + Mevaldate
NAD+ + 1-Propanol <-> NADH + H+ + Propanal
NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione
H+ + NADPH + Methylglyoxal <-> NADP+ + Hydroxyacetone
NADP+ + Indole-3-ethanol <-> H+ + NADPH + Indole-3-acetaldehyde
H+ + NADPH + Cinnamaldehyde <-> NADP+ + Cinnamyl alcohol
NADP+ + L-Gulono-1,4-lactone <-> H+ + NADPH + D-Glucurono-3,6-lactone
NADH + H+ + Butanal <-> NAD+ + 1-Butanol
H+ + NADPH + Butanal <-> NADP+ + 1-Butanol
NADP+ + sn-Glycerol 1-phosphate <-> Glycerone phosphate + H+ + NADPH
NAD+ + 3-Methylbutanol <-> NADH + H+ + 3-Methylbutanal
NADP+ + 3-Methylbutanol <-> H+ + NADPH + 3-Methylbutanal
NADP+ + Alcohol <-> H+ + NADPH + (+)-Camphorquinone
H+ + NADPH + 4-Cyanobenzaldehyde <-> NADP+ + 4-Cyanobenzyl alcohol
H+ + NADPH + 4-Carboxybenzaldehyde <-> NADP+ + 4-Carboxybenzyl alcohol
H+ + NADPH + 3-Pyridinecarboxaldehyde <-> NADP+ + 3-Pyridinemethanol
NADP+ + Acenaphthen-1-ol <-> H+ + NADPH + 1-Acenaphthenone
H+ + NADPH + Benzaldehyde <-> NADP+ + Benzyl alcohol
H+ + NADPH + Glyceraldehyde <-> NADP+ + Glycerol
H+ + NADPH + D-Ribose <-> NADP+ + Ribitol
H+ + NADPH + Glycolaldehyde <-> NADP+ + Glycol
H+ + NADPH + m-Nitrobenzaldehyde <-> NADP+ + m-Nitrobenzyl alcohol
H+ + NADPH + Octadecanal <-> NADP+ + Stearyl alcohol
H+ + NADPH + o-Nitrobenzaldehyde <-> NADP+ + o-Nitrobenzyl alcohol
H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol
NADH + H+ + Glyceraldehyde <-> NAD+ + Glycerol
H+ + NADPH + Propanal <-> NADP+ + 1-Propanol
H+ + NADPH + Pyridine-3-aldehyde <-> NADP+ + 3-Pyridinemethanol
H+ + NADPH + Glucose <-> NADP+ + Sorbitol
H+ + NADPH + 3-Chlorobenzaldehyde <-> NADP+ + 3-Chlorobenzyl alcohol
H+ + NADPH + 3-Methoxybenzaldehyde <-> NADP+ + 3-Methoxybenzyl alcohol
H+ + NADPH + 4-Hydroxyphenylacetaldehyde <-> NADP+ + 4-Hydroxyphenylethanol
H+ + NADPH + 4-Hydroxyphenylglycolaldehyde <-> NADP+ + 4-Hydroxyphenylethyl alcohol
H+ + NADPH + 4-Methoxybenzaldehyde <-> NADP+ + 4-Methoxybenzyl alcohol
H+ + NADPH + 4-Tolualdehyde <-> NADP+ + Toluene
NAD+ + 1-Pentanol <-> NADH + H+ + 1-Pentanal
NAD+ + 1-Hexanol <-> NADH + H+ + Hexanal
H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol
H+ + NADPH + 2-Deoxy-D-glucose <-> NADP+ + 2-Deoxy-D-sorbitol
H+ + NADPH + 1-Pentanal <-> NADP+ + 1-Pentanol
H+ + NADPH + Hexanal <-> NADP+ + 1-Hexanol
H+ + NADPH + 2-Butanone <-> NADP+ + 2-Butanol
H+ + NADPH + 4-Nitroacetophenone <-> NADP+ + 1-(4-Nitrophenyl)ethanol
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol
H+ + NADPH + Cyclohexanone <-> NADP+ + Cyclohexanol
H+ + NADPH + Dimethylglyoxal <-> NADP+ + Acetoin
NADH + H+ + Pyridine-4-aldehyde <-> NAD+ + 4-Pyridinemethanol
H+ + NADPH + 2-Nitrobenzaldehyde <-> NADP+ + 2-Nitrobenzyl alcohol
NADP+ + Lactaldehyde <-> H+ + NADPH + Methylglyoxal
H+ + NADPH + 13-cis-Retinal <-> NADP+ + 13-cis-Retinol
NADPH + Benzalacetone <-> Unknown + NADP+
H+ + NADPH + all-trans-Retinal <-> NADP+ + Retinol
H+ + NADPH + D-Galacturonate <-> NADP+ + L-Galactonate
H+ + NADPH + Phenylglyoxal <-> NADP+ + 2-Hydroxyacetophenone
H+ + NADPH + Ethyl 3-oxobutanoate <-> NADP+ + Ethyl 3-hydroxybutanoate
H+ + NADPH + L-Glyceraldehyde <-> NADP+ + Glycerol
H+ + NADPH + Cyclohexan-1,2-dione <-> NADP+ + 2-Hydroxycyclohexanone
H+ + NADPH + Dodecanal <-> NADP+ + 1-Dodecanol
NADP+ + trans-2-Hexenol <-> H+ + NADPH + trans-2-Hexenal
H+ + NADPH + Heptanal <-> NADP+ + Heptanol
NADH + H+ + 2-Methylbutanal <-> NAD+ + 2-Methylbutanol
NADH + H+ + Heptanal <-> NAD+ + Heptanol
H+ + NADPH + 2-Methylbutanal <-> NADP+ + 2-Methylbutanol
H+ + NADPH + D-Lactaldehyde <-> NADP+ + 1,2-Propanediol
H+ + NADPH + Hydroxyacetone <-> NADP+ + 1,2-Propanediol
H+ + NADPH + Glyceraldehyde 3-phosphate <-> NADP+ + sn-Glycerol 3-phosphate
NADP+ + (S)-4-Phenyl-2-butanol <-> H+ + NADPH + Benzylacetone
H+ + NADPH + Phenylacetone <-> NADP+ + (S)-1-Phenyl-2-propanol
H+ + NADPH + Succinate semialdehyde <-> NADP+ + 4-Hydroxybutanoate
H+ + NADPH + 2-Chlorobenzaldehyde <-> NADP+ + 2-Chlorobenzyl alcohol
H+ + NADPH + 4-Chlorobenzaldehyde <-> NADP+ + p-Chlorobenzyl alcohol
H+ + NADPH + 1-Octanal <-> NADP+ + 1-Octanol
H+ + NADPH + Pyridine-2-aldehyde <-> NADP+ + 2-Pyridinylmethanol
H+ + NADPH + 2-Carboxybenzaldehyde <-> NADP+ + 2-(Hydroxymethyl)benzoic acid
H+ + NADPH + Pyridine-4-aldehyde <-> NADP+ + 4-Pyridinemethanol
H+ + NADPH + 1,2-Naphthoquinone <-> NADP+ + Naphthalene-1,2-diol
H+ + NADPH + Isatin <-> NADP+ + 2,3-Dihydroxyindole
H+ + NADPH + 16-Ketoestrone <-> NADP+ + 16-Hydroxyestrone
H+ + NADPH + 16-Hexadecanal <-> NADP+ + 1-Hexadecanol
H+ + NADPH + N,N-Dimethyl-4-nitrosoaniline <-> NADP+ + N,N-Dimethyl-1,4-phenylenediamine
H+ + NADPH + N,N-Diethyl-4-nitrosoaniline <-> NADP+ + N,N-Diethyl-p-phenylenediamine
NADP+ + p-Nitrosophenol <-> H+ + NADPH + p-Nitrosocyclohexa-2,5-dien-1-one
H+ + NADPH + 4-Nitroso-N-phenylaniline <-> NADP+ + 4-Aminodiphenylamine
H+ + NADPH + p-Nitroso-N-dimethylaniline <-> NADP+ + N,N-Dimethyl-1,4-phenylenediamine
NADP+ + 5alpha-Androstane-17beta-ol-3-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione
H+ + NADPH + Aflatoxin B1 dihydrodiol <-> NADP+ + Aflatoxin B1 dialcohol
H+ + NADPH + 3-Oxopropanoate <-> NADP+ + 3-Hydroxypropanoate
NADP+ + (R)-2-Butanol <-> H+ + NADPH + 2-Butanone
NADH + H+ + Methyl acetoacetate <-> NAD+ + Methyl 3-hydroxybutanoate
NADH + H+ + Acetone <-> NAD+ + 2-Propanol
H+ + NADPH + Methyl acetoacetate <-> NADP+ + Methyl 3-hydroxybutanoate
H+ + NADPH + Acetone <-> NADP+ + 2-Propanol
2 H+ + 2 NADPH + Camphorquinone <-> 2 NADP+ + 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol
H+ + NADPH + 4-Hydroxybenzaldehyde <-> NADP+ + p-Hydroxybenzyl alcohol
NADP+ + Coniferyl alcohol <-> H+ + NADPH + Coniferaldehyde
NADPH + Crotonaldehyde <-> NADP+ + 2-Buten-1-ol
H+ + NADPH + Adriamycin <-> NADP+ + Doxorubicinol
NADP+ + NADP+ + 5beta-Androstane-17beta-ol-3-one + 5beta-Androstane-17beta-ol-3-one <-> H+ + H+ + NADPH + NADPH + 5beta-Androstane-3,17-dione + 5beta-Androstane-3,17-dione
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.1.1.2



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