Enzyme Details

 EC Classification 1.1.1.21
 Enzyme name
(recommended)
aldehyde reductase
 Alternative names alditol:NAD(P)+ 1-oxidoreductase
aldose reductase
polyol dehydrogenase (NADP+)
ALR2
alditol:NADP+ oxidoreductase
alditol:NADP+ 1-oxidoreductase
NADPH-aldopentose reductase
NADPH-aldose reductase
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
Ethanol + NADP+ <-> H+ + NADPH + Acetaldehyde
NAD+ + Alditol <-> NADH + H+ + Aldose
NADP+ + Glycolate <-> H+ + NADPH + Glyoxylate
NADP+ + Alditol <-> H+ + NADPH + Aldose
NADP+ + Glycerol <-> H+ + NADPH + D-Glyceraldehyde
NAD+ + Lactaldehyde <-> NADH + H+ + Methylglyoxal
NADP+ + 1,2-Propanediol <-> H+ + NADPH + Lactaldehyde
H2O + NADP+ + Succinate semialdehyde <-> H+ + NADPH + Succinate
NADP+ + sn-Glycerol 3-phosphate <-> D-Glyceraldehyde 3-phosphate + H+ + NADPH
NAD+ + Glycerol <-> NADH + H+ + D-Glyceraldehyde
NADP+ + Glycerol <-> H+ + NADPH + Dihydroxyacetone
NADH + H+ + D-Galactose <-> NAD+ + Galactitol
H+ + NADPH + D-Galactose <-> NADP+ + Galactitol
NADP+ + Xylitol <-> H+ + NADPH + D-Xylose
NADP+ + L-Gulonate <-> H+ + NADPH + D-Glucuronate
NAD+ + L-Arabitol <-> NADH + H+ + L-Arabinose
NADP+ + L-Arabitol <-> H+ + NADPH + L-Arabinose
NAD+ + Benzyl alcohol <-> NADH + H+ + Benzaldehyde
NADP+ + D-Sorbitol <-> H+ + NADPH + alpha-D-Glucose
NADP+ + 1,2-Propanediol <-> H+ + NADPH + L-Lactaldehyde
NAD+ + 1-Propanol <-> NADH + H+ + Propanal
NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione
H+ + NADPH + Methylglyoxal <-> NADP+ + Hydroxyacetone
NADP+ + Indole-3-ethanol <-> H+ + NADPH + Indole-3-acetaldehyde
NADP+ + L-Gulono-1,4-lactone <-> H+ + NADPH + D-Glucurono-3,6-lactone
NADH + H+ + Butanal <-> NAD+ + 1-Butanol
H+ + NADPH + Butanal <-> NADP+ + 1-Butanol
NADP+ + 2-Propen-1-ol <-> H+ + NADPH + Acrolein
NAD+ + alpha-Hydroxy-p-xylene <-> NADH + H+ + p-Tolualdehyde
NAD+ + 3-Methylbenzyl alcohol <-> NADH + H+ + 3-Methylbenzaldehyde
NADP+ + sn-Glycerol 1-phosphate <-> Glycerone phosphate + H+ + NADPH
NADP+ + 3-Methylbutanol <-> H+ + NADPH + 3-Methylbutanal
NADH + H+ + D-Xylose <-> NAD+ + Xylitol
NADP+ + Mannitol <-> H+ + NADPH + D-Fructose
H+ + NADPH + 4-Cyanobenzaldehyde <-> NADP+ + 4-Cyanobenzyl alcohol
H+ + NADPH + 3-Pyridinecarboxaldehyde <-> NADP+ + 3-Pyridinemethanol
H+ + NADPH + Benzaldehyde <-> NADP+ + Benzyl alcohol
H+ + NADPH + D-Erythrose <-> NADP+ + Erythritol
H+ + NADPH + Glyceraldehyde <-> NADP+ + Glycerol
H+ + NADPH + D-Ribose <-> NADP+ + Ribitol
H+ + NADPH + Glycolaldehyde <-> NADP+ + Glycol
H+ + NADPH + m-Nitrobenzaldehyde <-> NADP+ + m-Nitrobenzyl alcohol
H+ + NADPH + o-Nitrobenzaldehyde <-> NADP+ + o-Nitrobenzyl alcohol
H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol
NADH + H+ + Glyceraldehyde <-> NAD+ + Glycerol
H+ + NADPH + Propanal <-> NADP+ + 1-Propanol
H+ + NADPH + Pyridine-3-aldehyde <-> NADP+ + 3-Pyridinemethanol
H+ + NADPH + Glucose <-> NADP+ + Sorbitol
H+ + NADPH + 3-Chlorobenzaldehyde <-> NADP+ + 3-Chlorobenzyl alcohol
H+ + NADPH + 3-Methoxybenzaldehyde <-> NADP+ + 3-Methoxybenzyl alcohol
H+ + NADPH + 4-Hydroxyphenylacetaldehyde <-> NADP+ + 4-Hydroxyphenylethanol
H+ + NADPH + 4-Hydroxyphenylglycolaldehyde <-> NADP+ + 4-Hydroxyphenylethyl alcohol
H+ + NADPH + 4-Methoxybenzaldehyde <-> NADP+ + 4-Methoxybenzyl alcohol
NAD+ + 1-Pentanol <-> NADH + H+ + 1-Pentanal
NADH + H+ + m-Nitrobenzaldehyde <-> NAD+ + m-Nitrobenzyl alcohol
NAD+ + 1-Hexanol <-> NADH + H+ + Hexanal
H+ + NADPH + D-Fucose <-> NADP+ + D-Fucitol
H+ + NADPH + D-Mannose <-> NADP+ + Mannitol
H+ + NADPH + L-Idose <-> NADP+ + L-Iditol
H+ + NADPH + D-Lyxose <-> NADP+ + D-Arabitol
H+ + NADPH + 2-Deoxy-D-glucose <-> NADP+ + 2-Deoxy-D-sorbitol
H+ + NADPH + 2-Deoxy-D-ribose <-> NADP+ + 2-Deoxy-D-ribitol
H+ + NADPH + 2-Deoxy-D-galactose <-> NADP+ + 2-Deoxy-D-galacitol
H+ + NADPH + 1-Pentanal <-> NADP+ + 1-Pentanol
H+ + NADPH + Hexanal <-> NADP+ + 1-Hexanol
NADH + H+ + D-Fucose <-> NAD+ + Fucitol
NADH + H+ + D-Ribose <-> NAD+ + Ribitol
NADH + H+ + L-Idose <-> NAD+ + Idositol
NADH + H+ + D-Mannose <-> NAD+ + D-Mannitol
NADH + H+ + D-Erythrose <-> NAD+ + D-Erythrol
NADH + H+ + 2-Deoxy-D-glucose <-> NAD+ + 2-Deoxy-D-sorbitol
NADH + H+ + 2-Deoxy-D-galactose <-> NAD+ + 2-Deoxy-D-galacitol
H+ + NADPH + L-Lyxose <-> NADP+ + L-Arabitol
NADH + H+ + L-Lyxose <-> NAD+ + L-Arabitol
H+ + NADPH + D-Glucose <-> NADP+ + D-Sorbitol
NADH + H+ + D-Glucose <-> NAD+ + D-Sorbitol
NADH + H+ + D-Lyxose <-> NAD+ + D-Arabitol
H+ + NADPH + Dimethylglyoxal <-> NADP+ + Acetoin
NADP+ + Lactaldehyde <-> H+ + NADPH + Methylglyoxal
NADH + H+ + Methylglyoxal <-> NAD+ + Hydroxyacetone
NADH + H+ + Acrolein <-> NAD+ + 2-Propen-1-ol
H+ + NADPH + Glyoxal <-> NADP+ + Glycolaldehyde
H+ + NADPH + D-Galacturonate <-> NADP+ + L-Galactonate
H+ + NADPH + Phenylglyoxal <-> NADP+ + 2-Hydroxyacetophenone
H+ + NADPH + Ethyl 3-oxobutanoate <-> NADP+ + Ethyl 3-hydroxybutanoate
H+ + NADPH + L-Glyceraldehyde <-> NADP+ + Glycerol
H+ + NADPH + Cyclohexan-1,2-dione <-> NADP+ + 2-Hydroxycyclohexanone
H+ + NADPH + Heptanal <-> NADP+ + Heptanol
H+ + NADPH + 2-Methylbutanal <-> NADP+ + 2-Methylbutanol
H+ + NADPH + L-Xylose <-> NADP+ + Xylitol
H+ + NADPH + 9-cis-Retinal <-> NADP+ + 9-cis-Retinol
H+ + NADPH + 2-Fluoro-D-glucose <-> NADP+ + 2-Fluoro-D-sorbitol
H+ + NADPH + 6-Deoxy-D-glucose <-> NADP+ + 6-Deoxy-D-sorbitol
H+ + NADPH + 6-Fluoro-D-glucose <-> NADP+ + 6-Fluoro-D-sorbitol
H+ + NADPH + 4-Fluoro-D-glucose <-> NADP+ + 4-Fluoro-D-sorbitol
H+ + NADPH + 3-Fluoro-D-glucose <-> NADP+ + 3-Fluoro-D-sorbitol
H+ + NADPH + 5-Thio-D-glucose <-> NADP+ + 5-Thio-D-sorbitol
H+ + NADPH + D-Lactaldehyde <-> NADP+ + 1,2-Propanediol
H+ + NADPH + 20alpha-Isocorticosterone <-> Unknown + NADP+
H+ + NADPH + Hydroxyacetone <-> NADP+ + 1,2-Propanediol
H+ + NADPH + Glyceraldehyde 3-phosphate <-> NADP+ + sn-Glycerol 3-phosphate
H+ + NADPH + 20alpha-Isocortisol <-> Unknown + NADP+
NADH + H+ + m-Fluorobenzaldehyde <-> NAD+ + m-Fluorobenzyl alcohol
NADH + H+ + 3-Bromobenzaldehyde <-> NAD+ + 3-Bromobenzyl alcohol
NADH + H+ + 4-Cyanobenzaldehyde <-> NAD+ + 4-Cyanobenzyl alcohol
NADH + H+ + 3-Cyanobenzaldehyde <-> NAD+ + 3-Cyanobenzyl alcohol
NADH + H+ + 4-Chlorobenzaldehyde <-> NAD+ + p-Chlorobenzyl alcohol
H+ + NADPH + m-Fluorobenzaldehyde <-> NADP+ + m-Fluorobenzyl alcohol
NADH + H+ + 4-Fluorobenzaldehyde <-> NAD+ + p-Fluorobenzyl alcohol
NADH + H+ + 3-Chlorobenzaldehyde <-> NAD+ + 3-Chlorobenzyl alcohol
H+ + NADPH + 2-Chlorobenzaldehyde <-> NADP+ + 2-Chlorobenzyl alcohol
H+ + NADPH + 4-Methylphenylglyoxal <-> NADP+ + 4-Methylbenzoyl methanol
H+ + NADPH + 4-Chlorobenzaldehyde <-> NADP+ + p-Chlorobenzyl alcohol
H+ + NADPH + 3-Methylbenzaldehyde <-> NADP+ + 3-Methylbenzyl alcohol
H+ + NADPH + 3-Cyanobenzaldehyde <-> NADP+ + 3-Cyanobenzyl alcohol
H+ + NADPH + 2,4-Dimethylphenylglyoxal <-> NADP+ + 2,4-Dimethylbenzoyl methanol
H+ + NADPH + 2,3-Diketo-D-glucose <-> Unknown + NADP+
H+ + NADPH + 2-Methylpropanal <-> NADP+ + Isobutanol
H+ + NADPH + 3-Bromobenzaldehyde <-> NADP+ + 3-Bromobenzyl alcohol
H+ + NADPH + 2-Ethylbutanal <-> NADP+ + 2-Ethylbutanol
H+ + NADPH + 4-Fluorobenzaldehyde <-> NADP+ + p-Fluorobenzyl alcohol
NADH + H+ + 4-Methoxybenzaldehyde <-> NAD+ + 4-Methoxybenzyl alcohol
H+ + NADPH + 4-Chlorophenylglyoxal <-> NADP+ + 4-Chlorobenzoyl methanol
H+ + NADPH + p-Tolualdehyde <-> NADP+ + alpha-Hydroxy-p-xylene
H+ + NADPH + Phenylacetaldehyde <-> NADP+ + Phenylethyl alcohol
H+ + NADPH + 4-Bromophenylglyoxal <-> NADP+ + 4-Bromobenzoyl methanol
H+ + NADPH + D-Allose <-> NADP+ + D-Allitol
NADH + H+ + 4-Bromobenzaldehyde <-> NAD+ + 4-Bromobenzyl alcohol
H+ + NADPH + 4-Methoxyphenylglyoxal <-> NADP+ + 4-Methoxybenzoyl methanol
H+ + NADPH + Nonanal <-> NADP+ + 1-Nonanol
NADH + H+ + 3-Methoxybenzaldehyde <-> NAD+ + 3-Methoxybenzyl alcohol
H+ + NADPH + 4-Benzoyloxyphenylglyoxal <-> NADP+ + 4-Benzoyloxybenzoyl methanol
H+ + NADPH + 2,2-Dimethylpropanal <-> NADP+ + 2,2-Dimethylpropanol
H+ + NADPH + 2-Naphthaldehyde <-> NADP+ + (2-Naphthyl)methanol
H+ + NADPH + 4-Hydroxy-2-nonenal <-> NADP+ + 4-Hydroxynonenol
H+ + NADPH + Formaldehyde <-> Methanol + NADP+
H+ + NADPH + 1-Octanal <-> NADP+ + 1-Octanol
H+ + NADPH + 2,4,6-Trimethylphenylglyoxal <-> NADP+ + 2,4,6-Trimethylbenzoyl methanol
H+ + NADPH + 2-Keto-D-allose <-> Unknown + NADP+
H+ + NADPH + 2-Methylpentanal <-> NADP+ + 2-Methylpentanol
H+ + NADPH + 4-Bromobenzaldehyde <-> NADP+ + 4-Bromobenzyl alcohol
H+ + NADPH + 3-Methoxyphenylglyoxal <-> NADP+ + 3-Methoxybenzoyl methanol
H+ + NADPH + 4-Phenylphenylglyoxal <-> NADP+ + 4-Phenylbenzoyl methanol
H+ + NADPH + Pyridine-2-aldehyde <-> NADP+ + 2-Pyridinylmethanol
H+ + NADPH + D-Xylosone <-> Unknown + NADP+
H+ + NADPH + Glucosone <-> Unknown + NADP+
H+ + NADPH + 1-Naphthaldehyde <-> NADP+ + 1-Hydroxymethylnaphthalene
H+ + NADPH + 3-O-Methyl-D-glucose <-> NADP+ + 3-O-Methyl-D-sorbitol
H+ + NADPH + Malondialdehyde <-> NADP+ + 3-Hydroxypropanal
H+ + NADPH + Pyridine-4-aldehyde <-> NADP+ + 4-Pyridinemethanol
NADP+ + Gulonate <-> H+ + NADPH + Glucuronate
H+ + NADPH + D-Arabinose <-> NADP+ + D-Arabitol
H+ + NADPH + (S)-all-trans-4-Hydroxyretinal <-> NADP+ + (S)-all-trans-4-Hydroxyretinol
NADH + H+ + p-Nitrobenzaldehyde <-> NAD+ + p-Nitrobenzyl alcohol
H+ + NADPH + 4-Carboxybenzaldehyde <-> NADP+ + 4-Carboxybenzyl alcohol
NADP+ + L-Lactaldehyde <-> H+ + NADPH + Methylglyoxal
2 H+ + 2 NADPH + Dimethylglyoxal <-> 2 NADP+ + 2,3-Butanediol
H+ + NADPH + 2-Benzoylpyridine <-> NADP+ + Phenyl(pyridin-2-yl)methanol
H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol
NADPH + 1-Palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphatidylcholine <-> NAD+ + 1-Palmitoyl-2-(5-hydroxyvaleroyl)-sn-glycero-3-phosphatidylcholine
NADP+ + Aldose reductase <-> Enzyme-NADP+ complex
NADPH + Aldose reductase <-> Enzyme-NADPH complex
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.1.1.21



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