Enzyme Details

 EC Classification 1.1.1.213
 Enzyme name
(recommended)
3alpha-hydroxysteroid dehydrogenase (A-specific)
 Alternative names 3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NADP+ + Testosterone <-> H+ + NADPH + Androst-4-ene-3,17-dione
H+ + NADPH + Progesterone <-> NADP+ + 5beta-Pregnane-3,20-dione
NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione
NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione
NADP+ + Indan-1-ol <-> H+ + NADPH + Indanone
NAD+ + 3alpha-Hydroxy-5beta-cholanate <-> NADH + H+ + 3-Oxo-5beta-cholanate
NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione
NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> H+ + NADPH + 5beta-Androstane-3,17-dione
NAD+ + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> NADH + H+ + 7alpha-Hydroxy-5beta-cholestan-3-one
NADP+ + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> H+ + NADPH + 7alpha-Hydroxy-5beta-cholestan-3-one
NADP+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <-> H+ + NADPH + 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one
NAD+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> NADH + H+ + 5beta-Pregnane-3,20-dione
NADP+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione
NADP+ + 3beta-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione
NADP+ + Acenaphthen-1-ol <-> H+ + NADPH + 1-Acenaphthenone
NADP+ + Benzene dihydrodiol <-> H+ + NADPH + Catechol
H+ + NADPH + m-Nitrobenzaldehyde <-> NADP+ + m-Nitrobenzyl alcohol
H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol
H+ + NADPH + Pyridine-3-aldehyde <-> NADP+ + 3-Pyridinemethanol
H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol
NAD+ + 3alpha-Hydroxy-5alpha-pregnan-20-one <-> NADH + H+ + 5alpha-Pregnane-3,20-dione
NADP+ + (R)-Indan-1-ol <-> H+ + NADPH + Indanone
NADP+ + (S)-Indan-1-ol <-> H+ + NADPH + Indanone
H+ + NADPH + 4-Nitroacetophenone <-> NADP+ + 1-(4-Nitrophenyl)ethanol
NADH + H+ + 5alpha-Androstane-17beta-ol-3-one <-> NAD+ + 5alpha-Androstane-3alpha,17beta-diol
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol
H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol
H+ + NADPH + Dimethylglyoxal <-> NADP+ + Acetoin
H+ + NADPH + 2-Nitrobenzaldehyde <-> NADP+ + 2-Nitrobenzyl alcohol
H+ + NADPH + 4-Benzoylpyridine <-> Unknown + NADP+
H+ + NADPH + Menadione <-> NADP+ + Menadiol
NADH + H+ + p-Nitrobenzaldehyde <-> NAD+ + p-Nitrobenzyl alcohol
H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + Androstanediol
NADH + H+ + 9,10-Phenanthroquinone <-> NAD+ + Phenanthrene-9,10-diol
H+ + NADPH + 3-Oxo-5beta-cholanate <-> NADP+ + 3alpha-Hydroxy-5beta-cholanate
H+ + NADPH + Camphorquinone <-> Unknown + NADP+
NADP+ + Benzene dihydrodiol <-> H+ + NADPH + 2-Hydroxycyclohexa-3,5-diene-1-one
H+ + NADPH + 4-Chlorobenzaldehyde <-> NADP+ + p-Chlorobenzyl alcohol
NADP+ + 1,2,3,4-Tetrahydronaphth-1-ol <-> H+ + NADPH + alpha-Tetralone
H+ + NADPH + 20alpha-Hydroxy-5beta-pregnan-3-one <-> NADP+ + Pregnanediol
NAD+ + 5alpha-Pregnane-3alpha,21-diol-20-one <-> NADH + H+ + 5alpha-Pregnane-21-ol-3,20-dione
NAD+ + Glycolithocholate <-> NADH + H+ + 3-Oxo-5beta-glycocholanate
NAD+ + 5beta-Pregnane-3alpha,21-diol-20-one <-> NADH + H+ + 5beta-Pregnane-21-ol-3,20-dione
NAD+ + Glycochenodeoxycholic acid <-> NADH + H+ + 7alpha-Hydroxy-3-oxo-5-beta-cholanoyl glycinate
NADP+ + Glycolithocholate <-> H+ + NADPH + 3-Oxo-5beta-glycocholanate
NADP+ + 5beta-Pregnan-3alpha,21-diol-20-one <-> H+ + NADPH + 5beta-Pregnan-21-ol-3,20-dione
NADP+ + Glycochenodeoxycholate <-> H+ + NADPH + 7alpha-Hydroxy-3-oxo-5-beta-cholanoyl glycinate
H+ + NADPH + 5alpha-Pregnan-21-ol-3,20-dione <-> NADP+ + 5alpha-Pregnan-3alpha,21-diol-20-one
H+ + NADPH + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NADP+ + Tetrahydrocortisone
NADP+ + 5alpha-Pregnane-3alpha,21-diol-20-one <-> H+ + NADPH + 5alpha-Pregnane-21-ol-3,20-dione
NADH + H+ + 5alpha-Pregnan-21-ol-3,20-dione <-> NAD+ + 5alpha-Pregnan-3alpha,21-diol-20-one
NADH + H+ + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NAD+ + Tetrahydrocortisone
H+ + NADPH + 6-tert-Butyl-2,3-epoxy-5-cyclohexene-1,4-dione <-> NADP+ + 6-tert-Butyl-2,3-epoxy-4(S)-hydroxy-5-cyclohexene-1-one
NADH + H+ + 6-tert-Butyl-2,3-epoxy-5-cyclohexene-1,4-dione <-> NAD+ + 6-tert-Butyl-2,3-epoxy-4(S)-hydroxy-5-cyclohexene-1-one
H+ + NADPH + t-Butyl-p-benzoquinone <-> NADP+ + t-Butyl-p-hydrobenzoquinone
NADH + H+ + Dihydrocortisone <-> NAD+ + Tetrahydrocortisone
NADP+ + Tetrahydrocortisone <-> H+ + NADPH + Dihydrocortisone
NADP+ + 5alpha-Androstane-17beta-ol-3-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione
2 NADP+ + trans-Cyclohexa-3,5-diene-1,2-diol <-> 2 H+ + 2 NADPH + 2-Hydroxycyclohexa-3,5-diene-1-one
NADP+ + 3alpha-Hydroxyhexobarbital <-> H+ + NADPH + 3-Oxohexobarbital
NADP+ + 3beta-Hydroxyhexobarbital <-> H+ + NADPH + 3-Oxohexobarbital
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.1.1.213



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