Enzyme Details

 EC Classification 1.1.1.27
 Enzyme name
(recommended)
L-lactate dehydrogenase
 Alternative names (S)-lactate:NAD+ oxidoreductase
lactic acid dehydrogenase
L(+)-nLDH
L-(+)-lactate dehydrogenase
L-lactic dehydrogenase
L-lactic acid dehydrogenase
lactate dehydrogenase
lactate dehydrogenase NAD+-dependent
lactic dehydrogenase
NAD+-lactate dehydrogenase
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NAD+ + L-Lactate <-> Pyruvate + NADH + H+
NAD+ + L-Malate <-> NADH + H+ + Oxaloacetate
NAD+ + D-Lactate <-> Pyruvate + NADH + H+
NAD+ + D-Glycerate <-> NADH + H+ + 3-Hydroxypyruvate
NAD+ + 2-Hydroxybutyrate <-> NADH + H+ + 2-Oxobutyrate
NAD+ + Phenyllactate <-> NADH + H+ + Phenylpyruvate
NADH + H+ + 2-Oxoadipate <-> NAD+ + 2-Hydroxyadipate
NAD+ + Hydroxymalonate <-> NADH + H+ + Oxomalonate
NAD+ + 3-Mercaptolactate <-> NADH + H+ + 3-Mercaptopyruvate
L-Lactate + 3-Acetylpyridine-adenine dinucleotide <-> Pyruvate + H+ + Reduced 3-acetylpyridine-adenine dinucleotide
NADH + H+ + 2-Oxoglutarate <-> NAD+ + 2-Hydroxyglutarate
NADH + H+ + 4-Methyl-2-oxopentanoate <-> NAD+ + 2-Hydroxyisocaproate
NADH + H+ + 2-Oxopentanoate <-> NAD+ + 2-Hydroxyvalerate
NADH + H+ + Phenylpyruvate <-> NAD+ + 2-Hydroxy-3-phenylpropanoic acid
NADH + H+ + 3-Hydroxypyruvate <-> NAD+ + Glycerate
NADH + H+ + alpha-Ketovaline <-> NAD+ + Hydroxyisovalerate
NAD+ + 2-Oxooctanoate <-> NADH + H+ + 2-Hydroxyoctanoate
NADH + H+ + 2-Oxohexanoate <-> NAD+ + 2-Hydroxyhexanoate
NADH + H+ + 2-Oxo-4-aminobutyrate <-> NAD+ + 4-Amino-2-hydroxybutanoate
NADH + H+ + 6-Amino-2-oxohexanoate <-> NAD+ + 6-Amino-2-hydroxyhexanoate
Pyruvate + H+ + Deamino-NADH <-> L-Lactate + Deamino-NAD+
Pyruvate + H+ + NADPH <-> NADP+ + L-Lactate
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.1.1.27



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