Enzyme Details

 EC Classification 1.1.1.50
 Enzyme name
(recommended)
3alpha-hydroxysteroid dehydrogenase (B-specific)
 Alternative names 3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)
hydroxyprostaglandin dehydrogenase
3alpha-hydroxysteroid oxidoreductase
sterognost 3alpha
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NADP+ + trans-1,2-Dihydrobenzene-1,2-diol <-> H+ + NADPH + Catechol
H+ + NADPH + Progesterone <-> NADP+ + 5beta-Pregnane-3,20-dione
NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione
NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione
NADP+ + Indan-1-ol <-> H+ + NADPH + Indanone
NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione
NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> H+ + NADPH + 5beta-Androstane-3,17-dione
NAD+ + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> NADH + H+ + 7alpha-Hydroxy-5beta-cholestan-3-one
NADP+ + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> H+ + NADPH + 7alpha-Hydroxy-5beta-cholestan-3-one
NAD+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <-> NADH + H+ + 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one
NADP+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <-> H+ + NADPH + 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one
NAD+ + Urocortisol <-> NADH + H+ + 11beta,17alpha,21-Trihydroxy-5beta-pregnane-3,20-dione
NADP+ + Urocortisol <-> H+ + NADPH + 11beta,17alpha,21-Trihydroxy-5beta-pregnane-3,20-dione
NAD+ + 3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al <-> NADH + H+ + 11beta,21-Dihydroxy-3,20-oxo-5beta-pregnan-18-al
NADP+ + 3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al <-> H+ + NADPH + 11beta,21-Dihydroxy-3,20-oxo-5beta-pregnan-18-al
NAD+ + Tetrahydrocorticosterone <-> NADH + H+ + 11beta,21-Dihydroxy-5beta-pregnane-3,20-dione
NADP+ + Tetrahydrocorticosterone <-> H+ + NADPH + 11beta,21-Dihydroxy-5beta-pregnane-3,20-dione
NAD+ + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione <-> NADH + H+ + 21-Hydroxy-5beta-pregnane-3,11,20-trione
NADP+ + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione <-> H+ + NADPH + 21-Hydroxy-5beta-pregnane-3,11,20-trione
NAD+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> NADH + H+ + 5beta-Pregnane-3,20-dione
NADP+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione
H+ + NADPH + 1,4-Benzoquinone <-> NADP+ + Hydroquinone
NADP+ + 3beta-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione
NADP+ + Acenaphthen-1-ol <-> H+ + NADPH + 1-Acenaphthenone
NADP+ + Benzene dihydrodiol <-> H+ + NADPH + Catechol
H+ + NADPH + m-Nitrobenzaldehyde <-> NADP+ + m-Nitrobenzyl alcohol
H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol
H+ + NADPH + Pyridine-3-aldehyde <-> NADP+ + 3-Pyridinemethanol
NADP+ + 1,2-Dihydronaphthalene-1,2-diol <-> H+ + NADPH + Naphthalene-1,2-diol
H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol
NADP+ + (R)-Indan-1-ol <-> H+ + NADPH + Indanone
NADP+ + (S)-Indan-1-ol <-> H+ + NADPH + Indanone
H+ + NADPH + 4-Nitroacetophenone <-> NADP+ + 1-(4-Nitrophenyl)ethanol
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol
H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol
H+ + NADPH + Dimethylglyoxal <-> NADP+ + Acetoin
H+ + NADPH + 2-Nitrobenzaldehyde <-> NADP+ + 2-Nitrobenzyl alcohol
H+ + NADPH + 4-Benzoylpyridine <-> Unknown + NADP+
H+ + NADPH + Menadione <-> NADP+ + Menadiol
NADP+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate <-> H+ + NADPH + 3-Oxocholic acid
NADP+ + Chenodeoxycholate <-> H+ + NADPH + 3alpha-Hydroxy-7-oxo-5beta-cholanate
NADP+ + 3alpha,12alpha-Dihydroxy-5beta-cholanate <-> H+ + NADPH + 12alpha-Hydroxy-3-oxo-5beta-cholanate
H+ + NADPH + Duroquinone <-> NADP+ + Duroquinol
NADH + H+ + p-Nitrobenzaldehyde <-> NAD+ + p-Nitrobenzyl alcohol
H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + Androstanediol
NADH + H+ + 9,10-Phenanthroquinone <-> NAD+ + Phenanthrene-9,10-diol
NADH + H+ + 4-Nitroacetophenone <-> NAD+ + 1-(4-Nitrophenyl)ethanol
H+ + NADPH + 3-Oxo-5beta-cholanate <-> NADP+ + 3alpha-Hydroxy-5beta-cholanate
H+ + NADPH + Camphorquinone <-> Unknown + NADP+
NADP+ + Benzene dihydrodiol <-> H+ + NADPH + 2-Hydroxycyclohexa-3,5-diene-1-one
NADP+ + Ursodiol <-> H+ + NADPH + 7alpha,12alpha-dihydroxy-5beta-cholan-3-one-24-oic acid
NADP+ + 1,2,3,4-Tetrahydronaphth-1-ol <-> H+ + NADPH + alpha-Tetralone
H+ + NADPH + 20alpha-Hydroxy-5beta-pregnan-3-one <-> NADP+ + Pregnanediol
NAD+ + Acenaphthen-1-ol <-> NADH + H+ + 1-Acenaphthenone
NAD+ + Benzene dihydrodiol <-> NADH + H+ + Catechol
H+ + NADPH + 1,4-Naphthoquinone <-> NADP+ + 1,4-Dihydronaphthalen-4-ol-1-one
H+ + NADPH + Acetophenone <-> NADP+ + Acenaphthen-1-ol
H+ + NADPH + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NADP+ + Tetrahydrocortisone
NADH + H+ + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NAD+ + Tetrahydrocortisone
NADP+ + 5beta-Pregnan-3alpha,21-diol-20-one <-> H+ + NADPH + 5beta-Pregnan-21-ol-3,20-dione
NADP+ + Glycolithocholate <-> H+ + NADPH + 3-Oxo-5beta-glycocholanate
H+ + NADPH + 5alpha-Pregnane-2,20-dione <-> Unknown + NADP+
2 H+ + 2 NADPH + Acenaphthenequinone <-> 2 NADP+ + Acenaphthene-1,2-diol
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 3beta-Androstanediol
H+ + NADPH + 2,3-Heptanedione <-> NADP+ + 3-Hydroxyheptan-2-one
H+ + NADPH + 2,3-Hexanedione <-> NADP+ + 3-Hydroxyhexan-2-one
H+ + NADPH + 1-Phenyl-1,2-propanedione <-> Unknown + NADP+
H+ + NADPH + 2,3-Pentanedione <-> NADP+ + 3-Hydroxypentan-2-one
H+ + NADPH + Pyridine-4-aldehyde <-> NADP+ + 4-Pyridinemethanol
NAD+ + 3alpha,12alpha-Dihydroxy-5beta-cholanate <-> NADH + H+ + 12alpha-Hydroxy-3-oxo-5beta-cholanate
5alpha-Androstane-3alpha-ol-17-one + thio-NAD+ <-> H+ + 5alpha-Androstane-3,17-dione + thio-NADH
3alpha,12alpha-Dihydroxy-5beta-cholanate + thio-NAD+ <-> H+ + thio-NADH + 12alpha-Hydroxy-3-oxo-5beta-cholanate
NADP+ + 3alpha-Hydroxy-5alpha-pregnan-20-one <-> H+ + NADPH + 5alpha-Pregnane-3,20-dione
NADH + H+ + 5alpha-Androstane-17beta-ol-3-one <-> NAD+ + 5alpha-Androstane-3alpha,17beta-diol
NAD+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate <-> NADH + H+ + 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate
NAD+ + Fusidic acid <-> NADH + H+ + 3-Keto Fusidic Acid
NADH + H+ + Metyrapone <-> NAD+ + 2-Methyl-1,2-bis(3-pyridyl)-1-propanol
NADH + H+ + 2-(1-Imidazolyl)-1-(4-methoxyphenyl)-2-methyl-1-propanone <-> NAD+ + 1-(4-Methoxyphenyl)-2-methyl-2-(1H-imidazol-1-yl)-1-propanol
NAD+ + 5alpha-Androstane-3beta-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione
NADH + H+ + 5beta-Androstane-17beta-ol-3-one <-> NAD+ + 5beta-Androstane-3alpha,17beta-diol
NADH + H+ + 5alpha-Pregnanolone <-> NAD+ + 5alpha-Pregnanediol
NADH + H+ + 5beta-Pregnanolone <-> NAD+ + 5beta-Pregnanediol
NADH + H+ + 3-Dehydroecdysone <-> NAD+ + Ecdysone
NAD+ + Epiandrosterone <-> NADH + H+ + 5alpha-Androstane-3,17-dione
NAD+ + Androstanediol <-> NADH + H+ + 5alpha-Androstane-17beta-ol-3-one
NAD+ + 3alpha-Hydroxy Desogestrel <-> NADH + H+ + Etonogestrel
NAD+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate <-> NADH + H+ + 3-Oxocholic acid
NADH + H+ + 20alpha-Hydroxy-5beta-pregnan-3-one <-> NAD+ + 5beta-Pregnanediol
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


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