Enzyme Details

 EC Classification 1.1.1.51
 Enzyme name
(recommended)
3(or 17)beta-hydroxysteroid dehydrogenase
 Alternative names 3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
beta-hydroxy steroid dehydrogenase
17-ketoreductase
17beta-hydroxy steroid dehydrogenase
3beta-hydroxysteroid dehydrogenase
17beta-hydroxy steroid dehydrogenase
3beta-hydroxy steroid dehydrogenase
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NAD+ + Testosterone <-> NADH + H+ + Androst-4-ene-3,17-dione
NADP+ + Testosterone <-> H+ + NADPH + Androst-4-ene-3,17-dione
NAD+ + 20alpha-Hydroxy-4-pregnen-3-one <-> NADH + H+ + Progesterone
NAD+ + Estradiol-17beta <-> NADH + H+ + Estrone
NADP+ + Estradiol-17beta <-> H+ + NADPH + Estrone
NAD+ + 1-Propanol <-> NADH + H+ + Propanal
NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione
NAD+ + Cortisol <-> NADH + H+ + Cortisone
NAD+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one <-> NADH + H+ + 17alpha-Hydroxyprogesterone
NAD+ + Androst-5-ene-3beta,17beta-diol <-> NADH + H+ + 3beta-Hydroxyandrost-5-en-17-one
NADP+ + Androst-5-ene-3beta,17beta-diol <-> H+ + NADPH + 3beta-Hydroxyandrost-5-en-17-one
NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione
NAD+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> NADH + H+ + 5beta-Pregnane-3,20-dione
NADH + H+ + 5alpha-Androstane-17beta-ol-3-one <-> NAD+ + 5alpha-Androstane-3alpha,17beta-diol
NADH + H+ + Cyclohex-2-enone <-> NAD+ + Cyclohex-2-en-1-ol
NAD+ + (S)-Indan-1-ol <-> NADH + H+ + Indanone
NADH + H+ + p-Nitrobenzaldehyde <-> NAD+ + p-Nitrobenzyl alcohol
NADH + H+ + 9,10-Phenanthroquinone <-> NAD+ + Phenanthrene-9,10-diol
NADH + H+ + Prostaglandin D2 <-> NAD+ + 9alpha,11beta-Prostaglandin F2
NADH + H+ + 4-Chlorobenzaldehyde <-> NAD+ + p-Chlorobenzyl alcohol
H+ + NADPH + 4-Chlorobenzaldehyde <-> NADP+ + p-Chlorobenzyl alcohol
NADH + H+ + 5alpha-Androstane-3alpha-ol-17-one <-> NAD+ + 5alpha-Androstane-3alpha,17beta-diol
NAD+ + 5alpha-Androstane-17beta-ol-3-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione
NAD+ + 5beta-Androstane-3alpha,17beta-diol <-> NADH + H+ + 3alpha-Hydroxy-5beta-androstan-17-one
NAD+ + 5beta-Androstane-17beta-ol-3-one <-> NADH + H+ + 5beta-Androstane-3,17-dione
NADH + H+ + 21-Dehydrocortisol <-> NAD+ + Cortisol
H+ + NADPH + 6-tert-Butyl-2,3-epoxy-5-cyclohexene-1,4-dione <-> NADP+ + 6-tert-Butyl-2,3-epoxy-4(R)-hydroxy-5-cyclohexene-1-one
H+ + NADPH + t-Butyl-p-benzoquinone <-> NADP+ + t-Butyl-p-hydrobenzoquinone
NADH + H+ + 6-tert-Butyl-2,3-epoxy-5-cyclohexene-1,4-dione <-> NAD+ + 6-tert-Butyl-2,3-epoxy-4(R)-hydroxy-5-cyclohexene-1-one
H+ + NADPH + 6-tert-Butyl-2,3-epoxy-5-cyclohexene-1,4-dione <-> NADP+ + 6-tert-Butyl-2,3-epoxy-4-hydroxy-5-cyclohexene-1-one
NADP+ + (S)-(+)-1,2,3,4-Tetrahydro-1-naphtol <-> H+ + NADPH + (S)-(+)-2,3,4-Trihydro-1-naphtone
NAD+ + (S)-(+)-1,2,3,4-Tetrahydro-1-naphtol <-> NADH + H+ + (S)-(+)-2,3,4-Trihydro-1-naphtone
2 NAD+ + trans-Cyclohexa-3,5-diene-1,2-diol <-> 2 NADH + 2 H+ + 2-Hydroxycyclohexa-3,5-diene-1-one
NAD+ + alpha-3-Hydroxyhexobarbital <-> NADH + H+ + 3-Oxohexobarbital
NAD+ + beta-3-Hydroxyhexobarbital <-> NADH + H+ + 3-Oxohexobarbital
NAD+ + 9alpha,11alpha-Prostaglandin F2 <-> NADH + H+ + Prostaglandin D2
NADH + H+ + Isatin <-> NAD+ + 2,3-Dihydroxyindole
2 NADH + 2 H+ + (1S)-(+)-Camphorquinone <-> 2 NAD+ + 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol
2 NADH + 2 H+ + (1R)-(-)-Camphorquinone <-> 2 NAD+ + 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol
NADH + H+ + 6-tert-Butyl-2,3-epoxy-5-cyclohexene-1,4-dione <-> NAD+ + 6-tert-Butyl-2,3-epoxy-4-hydroxy-5-cyclohexene-1-one
2 NADH + 2 H+ + 2,3-Pentanedione <-> 2 NAD+ + 2,3-Pentanediol
2 NADH + 2 H+ + Dimethylglyoxal <-> 2 NAD+ + 2,3-Butanediol
NAD+ + 20alpha-Hydroxy-5alpha-pregnan-3-one <-> NADH + H+ + 5alpha-Pregnane-3,20-dione
NAD+ + 4-Androsten-3alpha-ol-17-one <-> NADH + H+ + Androst-4-ene-3,17-dione
NADH + H+ + 4-Androsten-3alpha-ol-17-one <-> NAD+ + Androst-4-ene-3alpha,17beta-diol
NADH + H+ + 5beta-Pregnane-3,20-dione <-> NAD+ + 20alpha-Hydroxy-5beta-pregnan-3-one
NADH + H+ + 20alpha-Hydroxy-5beta-pregnan-3-one <-> NAD+ + Pregnanediol
NADH + H+ + 16-Ketoestrone <-> NAD+ + 16-Hydroxyestrone
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


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