Enzyme Details

 EC Classification 1.1.1.62
 Enzyme name
(recommended)
estradiol 17beta-dehydrogenase
 Alternative names estradiol-17beta:NAD(P)+ 17-oxidoreductase
20alpha-hydroxysteroid dehydrogenase
17beta,20alpha-hydroxysteroid dehydrogenase
17beta-estradiol dehydrogenase
estradiol dehydrogenase
estrogen 17-oxidoreductase
17beta-HSD
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NAD+ + Testosterone <-> NADH + H+ + Androst-4-ene-3,17-dione
NADP+ + Testosterone <-> H+ + NADPH + Androst-4-ene-3,17-dione
NADP+ + 20alpha-Hydroxy-4-pregnen-3-one <-> H+ + NADPH + Progesterone
NAD+ + Estradiol-17beta <-> NADH + H+ + Estrone
NADP+ + Estradiol-17beta <-> H+ + NADPH + Estrone
NADP+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one <-> H+ + NADPH + 17alpha-Hydroxyprogesterone
NADP+ + Androst-5-ene-3beta,17beta-diol <-> H+ + NADPH + 3beta-Hydroxyandrost-5-en-17-one
NAD+ + Estriol <-> NADH + H+ + 16alpha-Hydroxyestrone
NADP+ + Estriol <-> H+ + NADPH + 16alpha-Hydroxyestrone
H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol
H+ + NADPH + Prostaglandin D2 <-> NADP+ + 9alpha,11beta-Prostaglandin F2
H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol
NADP+ + (S)-Indan-1-ol <-> H+ + NADPH + Indanone
H+ + NADPH + 4-Nitroacetophenone <-> NADP+ + 1-(4-Nitrophenyl)ethanol
NADP+ + Cyclohex-2-en-1-ol <-> H+ + NADPH + Cyclohex-2-enone
H+ + NADPH + 5beta-Pregnane-3,20-dione <-> NADP+ + 20alpha-Hydroxy-5beta-pregnan-3-one
H+ + NADPH + 4-Chlorobenzaldehyde <-> NADP+ + p-Chlorobenzyl alcohol
H+ + NADPH + Isatin <-> NADP+ + 2,3-Dihydroxyindole
H+ + NADPH + 16-Ketoestrone <-> NADP+ + 16-Hydroxyestrone
H+ + NADPH + 21-Dehydrocortisol <-> NADP+ + Cortisol
H+ + NADPH + 5alpha-Androstane-3alpha-ol-17-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol
H+ + NADPH + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol
NADP+ + NADP+ + 5beta-Androstane-17beta-ol-3-one + 5beta-Androstane-17beta-ol-3-one <-> H+ + H+ + NADPH + NADPH + 5beta-Androstane-3,17-dione + 5beta-Androstane-3,17-dione
NADP+ + 5alpha-Androstane-17beta-ol-3-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione
H+ + NADPH + 6-tert-Butyl-2,3-epoxy-5-cyclohexene-1,4-dione <-> NADP+ + 6-tert-Butyl-2,3-epoxy-4-hydroxy-5-cyclohexene-1-one
NADP+ + (S)-(+)-1,2,3,4-Tetrahydro-1-naphtol <-> H+ + NADPH + (S)-(+)-2,3,4-Trihydro-1-naphtone
2 NADH + 2 H+ + (1R)-(-)-Camphorquinone <-> 2 NAD+ + 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol
2 NADP+ + trans-Cyclohexa-3,5-diene-1,2-diol <-> 2 H+ + 2 NADPH + 2-Hydroxycyclohexa-3,5-diene-1-one
NADP+ + 3alpha-Hydroxyhexobarbital <-> H+ + NADPH + 3-Oxohexobarbital
NADP+ + beta-3-Hydroxyhexobarbital <-> H+ + NADPH + 3-Oxohexobarbital
NADP+ + 9alpha,11alpha-Prostaglandin F2 <-> H+ + NADPH + Prostaglandin D2
2 H+ + 2 NADPH + (1S)-(+)-Camphorquinone <-> 2 NADP+ + 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol
2 H+ + 2 NADPH + (1R)-(-)-Camphorquinone <-> 2 NADP+ + 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol
2 H+ + 2 NADPH + 2,3-Pentanedione <-> 2 NADP+ + 2,3-Pentanediol
2 H+ + 2 NADPH + Dimethylglyoxal <-> 2 NADP+ + 2,3-Butanediol
H+ + NADPH + 2-Acetylpyridine <-> NADP+ + 1-(Pyridin-2-yl)ethanol
H+ + NADPH + 4-Androsten-3alpha-ol-17-one <-> NADP+ + Androst-4-ene-3alpha,17beta-diol
NAD+ + 5alpha-Androstane-17beta-ol-3-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.1.1.62



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