Enzyme Details

 EC Classification 1.14.13.39
 Enzyme name
(recommended)
nitric-oxide synthase
 Alternative names NADPH-diaphorase
L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
nitric oxide synthetase
endothelium-derived relaxation factor-forming enzyme
endothelium-derived relaxing factor synthase
NO synthase
 Classification
Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With NADH or NADPH as one donor, and incorporation of one atom of oxygen
 Catalyses reactions
H+ + NADPH + O2 + 2 N-(omega)-Hydroxyarginine <-> NADP+ + 2 L-Citrulline + 2 Nitric oxide
H+ + L-Arginine + NADPH + O2 <-> NADP+ + L-Citrulline + Nitric oxide
H+ + L-Arginine + NADPH + O2 <-> H2O + NADP+ + N-(omega)-Hydroxyarginine
NADH + 2 Hexacyanoferrate(III) <-> NAD+ + H+ + 2 Hexacyanoferrate(II)
NADPH + 2 Hexacyanoferrate(III) <-> H+ + NADP+ + 2 Hexacyanoferrate(II)
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.14.13.39



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