Enzyme Details

 EC Classification 1.2.1.3
 Enzyme name
(recommended)
aldehyde dehydrogenase (NAD+)
 Alternative names aldehyde:NAD+ oxidoreductase
CoA-independent aldehyde dehydrogenase
m-methylbenzaldehyde dehydrogenase
NAD-aldehyde dehydrogenase
NAD-dependent 4-hydroxynonenal dehydrogenase
NAD-dependent aldehyde dehydrogenase
NAD-linked aldehyde dehydrogenase
propionaldehyde dehydrogenase
aldehyde dehydrogenase (NAD)
 Classification
Oxidoreductases
Acting on the aldehyde or oxo group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NAD+ + H2O + Aldehyde <-> NADH + H+ + Acid
NAD+ + H2O + Glycolaldehyde <-> NADH + H+ + Glycolate
H2O + NADP+ + Acetaldehyde <-> H+ + NADPH + Acetate
NAD+ + H2O + Acetaldehyde <-> NADH + H+ + Acetate
NAD+ + H2O + Aldehyde <-> NADH + H+ + Carboxylate
NAD+ + H2O + Formaldehyde <-> NADH + H+ + Formate
NAD+ + H2O + Aldehyde <-> NADH + H+ + Fatty acid
NAD+ + 2 H2O + (S)-1-Pyrroline-5-carboxylate <-> NADH + H+ + L-Glutamate
NAD+ + H2O + Succinate semialdehyde <-> NADH + H+ + Succinate
NAD+ + H2O + beta-Aminopropion aldehyde <-> NADH + H+ + beta-Alanine
NAD+ + H2O + Benzaldehyde <-> NADH + H+ + Benzoate
H2O + NADP+ + Benzaldehyde <-> H+ + NADPH + Benzoate
NAD+ + H2O + 16-Hexadecanal <-> NADH + H+ + Palmitate
NAD+ + H2O + D-Glyceraldehyde <-> NADH + H+ + D-Glycerate
H2O + NADP+ + 4-Aminobutanal <-> H+ + NADPH + 4-Aminobutanoate
NAD+ + H2O + Phenylacetaldehyde <-> NADH + H+ + Phenylacetic acid
NAD+ + H2O + 4-Aminobutanal <-> NADH + H+ + 4-Aminobutanoate
NAD+ + H2O + Betaine aldehyde <-> NADH + H+ + Betaine
NAD+ + H2O + Indole-3-acetaldehyde <-> NADH + H+ + Indole-3-acetate
NAD+ + H2O + 2-Propyn-1-al <-> NADH + H+ + Propynoate
NAD+ + 2 H2O + D-Glucurono-3,6-lactone <-> NADH + H+ + D-Glucarate
NAD+ + H2O + 4-Trimethylammoniobutanal <-> NADH + H+ + 4-Trimethylammoniobutanoate
NAD+ + H2O + 3,4-Dihydroxyphenylacetaldehyde <-> NADH + H+ + 3,4-Dihydroxyphenylacetate
NAD+ + H2O + (S)-Methylmalonate semialdehyde <-> NADH + H+ + Methylmalonate
NAD+ + H2O + Imidazole-4-acetaldehyde <-> NADH + H+ + Imidazole-4-acetate
NAD+ + H2O + 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al <-> NADH + H+ + 3alpha,7alpha-Dihydroxy-5beta-cholestanate
NAD+ + H2O + 5-Hydroxyindoleacetaldehyde <-> NADH + H+ + 5-Hydroxyindoleacetate
NAD+ + H2O + N4-Acetylaminobutanal <-> NADH + H+ + 4-Acetamidobutanoate
NAD+ + H2O + 3-Butyn-1-al <-> NADH + H+ + 3-Butynoate
NAD+ + H2O + Chloroacetaldehyde <-> NADH + H+ + Chloroacetic acid
NAD+ + H2O + Perillyl aldehyde <-> NADH + H+ + Perillic acid
NAD+ + H2O + Butanal <-> NADH + H+ + Butanoate
NAD+ + H2O + 1-Octanal <-> NADH + H+ + Octanoate
NAD+ + H2O + Decanal <-> NADH + H+ + Decanoate
NAD+ + H2O + Hexanal <-> NADH + H+ + Hexanoate
NAD+ + H2O + Glutaral <-> NADH + H+ + 5-Oxopentanoate
NAD+ + H2O + Dodecanal <-> NADH + H+ + Dodecanoate
NAD+ + H2O + 2,4-Dinitrobenzaldehyde <-> NADH + H+ + 2,4-Dinitrobenzoate
NAD+ + H2O + 2-Naphthaldehyde <-> NADH + H+ + 2-Naphthoic acid
NAD+ + H2O + 2-quinolinone-4-carboxaldehyde <-> NADH + H+ + 2-quinolinone-4-carboxylate
NAD+ + H2O + Veratraldehyde <-> NADH + H+ + 3,4-Dimethoxybenzoate
NAD+ + H2O + 3-Pyridinecarboxaldehyde <-> NADH + H+ + Nicotinate
NAD+ + H2O + 4-Methoxy-1-naphthaldehyde <-> NADH + H+ + 4-Methoxy-1-naphtacetate
NAD+ + H2O + 5-Bromo-1-naphthaldehyde <-> NADH + H+ + 5-Bromo-1-naphthoate
NAD+ + H2O + 5-Methoxyindole-3-carboxaldehyde <-> NADH + H+ + 5-Methoxyindolecarboxylate
NAD+ + H2O + 5-Nitro-1-naphthaldehyde <-> NADH + H+ + 5-Nitro-1-naphthoate
NAD+ + H2O + 6,7-Dimethoxycoumarin-4-carboxaldehyde <-> NADH + H+ + 6,7-Dimethoxycoumarin-4-carboxylate
NAD+ + H2O + 6-(dimethylamino)-2-naphthaldehyde <-> NADH + H+ + 6-(dimethylamino)-2-naphthoate
NAD+ + H2O + 6-Methoxy-2-quinolinone-4-carboxaldehyde <-> NADH + H+ + 6-Methoxy-2-quinolinone-4-carboxylate
NAD+ + H2O + 7-(dimethylamino)coumarin-4-carboxaldehyde <-> NADH + H+ + 7-(dimethylamino)coumarin-4-carboxylate
NAD+ + H2O + 7-Acetoxycoumarin-4-carboxaldehyde <-> NADH + H+ + 7-Acetoxycoumarin-4-carboxylate
NAD+ + H2O + 7-Hydroxycoumarin-4-carboxaldehyde <-> NADH + H+ + 7-Hydroxycoumarin-4-carboxylate
NAD+ + H2O + 7-Methoxy-2-quinolinone-4-carboxaldehyde <-> NADH + H+ + 7-Methoxy-2-quinolinone-4-carboxylate
NAD+ + H2O + 7-Methoxycoumarin-4-carboxaldehyde <-> NADH + H+ + 7-Methoxycoumarin-4-carboxylate
NAD+ + H2O + Fluorene-2-carboxaldehyde <-> NADH + H+ + Fluorene-2-carboxylate
NAD+ + H2O + Cinnamaldehyde <-> NADH + H+ + Cinnamic acid
NAD+ + H2O + Heptanal <-> NADH + H+ + Heptanoate
NAD+ + H2O + Hydrocinnamaldehyde <-> NADH + H+ + Hydrocinnamate
NAD+ + H2O + Glyceraldehyde <-> NADH + H+ + Glycerate
NAD+ + H2O + Pentanal <-> NADH + H+ + Pentanoate
NAD+ + H2O + Phenanthrene-9-carboxaldehyde <-> NADH + H+ + Phenanthrene-9-carboxylate
H2O + NADP+ + Propanal <-> H+ + NADPH + Propanoate
NAD+ + H2O + Quinoline-3-carboxaldehyde <-> NADH + H+ + Quinoline-3-carboxylate
NAD+ + H2O + Quinoline-4-carboxaldehyde <-> NADH + H+ + 4-Quinolinecarboxylic acid
NAD+ + H2O + alpha-Phenylpropionaldehyde <-> NADH + H+ + alpha-Phenylpropionate
NAD+ + H2O + 3-Hydroxybenzaldehyde <-> NADH + H+ + 3-Hydroxybenzoate
NAD+ + H2O + 3-Methoxybenzaldehyde <-> NADH + H+ + m-Methoxybenzoate
NAD+ + H2O + m-Methylbenzaldehyde <-> NADH + H+ + m-Methylbenzoate
NAD+ + H2O + Salicylaldehyde <-> NADH + H+ + Salicylate
NAD+ + H2O + 2-Methoxybenzaldehyde <-> NADH + H+ + o-Methoxybenzoate
NAD+ + H2O + o-Methylbenzaldehyde <-> NADH + H+ + o-Toluate
NAD+ + H2O + o-Nitrobenzaldehyde <-> NADH + H+ + o-Nitrobenzoate
NAD+ + H2O + p-(dimethylamino)benzaldehyde <-> NADH + H+ + p-(dimethylamino)benzoate
NAD+ + H2O + p-(dimethylamino)cinnamaldehyde <-> NADH + H+ + p-(dimethylamino)cinnamate
NAD+ + H2O + 4-Methoxybenzaldehyde <-> NADH + H+ + 4-Methoxybenzoate
NAD+ + H2O + p-Tolualdehyde <-> NADH + H+ + Toluate
NAD+ + H2O + p-Nitrobenzaldehyde <-> NADH + H+ + p-Nitrobenzoate
NAD+ + H2O + p-Nitrocinnamaldehyde <-> NADH + H+ + p-Nitrocinnamate
NAD+ + H2O + trans-Cinnamaldehyde <-> NADH + H+ + trans-Cinnamate
2 NAD+ + 2 H2O + Malondialdehyde <-> 2 NADH + H+ + Malonate
NAD+ + H2O + 4-Hydroxy-2-nonenal <-> NADH + H+ + 4-Hydroxy-2-nonenoic acid
H2O + p-Nitrophenyl acetate <-> Acetate + p-Nitrophenol
H2O + p-Nitrophenyl propionate <-> Propanoate + p-Nitrophenol
NAD+ + H2O + Propanal <-> NADH + H+ + Propanoate
H2O + NADP+ + 20-CHO-Leukotriene B4 <-> H+ + NADPH + 20-COOH-Leukotriene B4
NAD+ + H2O + 20-CHO-6-trans-12-epi-Leukotriene B4 <-> NADH + H+ + 20-COOH-6-trans-12-epi-Leukotriene B4
NAD+ + H2O + Citral <-> NADH + H+ + 3,7-Dimethylocta-2,6-dienoic acid
NAD+ + H2O + Geranial <-> NADH + H+ + (2E)-3,7-Dimethylocta-2,6-dienoic acid
NAD+ + H2O + 20-CHO-Leukotriene B4 <-> NADH + H+ + 20-COOH-Leukotriene B4
NAD+ + H2O + cis-Citral <-> NADH + H+ + (2Z)-3,7-Dimethylocta-2,6-dienoic acid
H2O + Propanal + 3-Acetylpyridine-adenine dinucleotide <-> H+ + Propanoate + Reduced 3-acetylpyridine-adenine dinucleotide
NAD+ + H2O + 4-Carboxybenzaldehyde <-> NADH + H+ + Terephthalate
H2O + Deamino-NAD+ + Propanal <-> H+ + Propanoate + Deamino-NADH
NAD+ + H2O + 3-Methylbutanal <-> NADH + H+ + Isovaleric acid
NAD+ + H2O + L-Glyceraldehyde <-> NADH + H+ + L-Glycerate
NAD+ + H2O + 3,4-Dihydroxyphenylglycolaldehyde <-> NADH + H+ + 3,4-Dihydroxyphenylglycolate
H2O + p-(dimethylamino)cinnamoylimidazole <-> Imidazole + p-(dimethylamino)cinnamate
NAD+ + H2O + Glyceraldehyde 3-phosphate <-> Glycerate 3-phosphate + NADH + H+
NAD+ + H2O + Glutathione-4-Oxonon-2-enal <-> NADH + H+ + Glutathione-4-Oxonon-2-enoic acid
NAD+ + H2O + 4-Guanidinobutanal <-> NADH + H+ + 4-Guanidinobutanoate
NAD+ + H2O + 5-Aminopentanal <-> NADH + H+ + 5-Aminopentanoate
NAD+ + H2O + N-(3-Propanal)-1,4-diaminobutane <-> NADH + H+ + Carboxyethyl putrescine
NAD+ + H2O + N-(3-Aminopropyl)-N'-(3-propanal)-1,4-diaminobutane <-> NADH + H+ + Carboxyethyl spermidine
NAD+ + H2O + N,N'-Bis(3-propanal)-1,4-diaminobutane <-> NADH + H+ + N-(3-Propanal)-N'-(3-propanoyl)-1,4-diaminobutane
NAD+ + H2O + 5-Imidazoleacetaldehyde <-> NADH + H+ + 5-Imidazoleacetate
NAD+ + H2O + Acrolein <-> NADH + H+ + Acrylate
NAD+ + H2O + all-trans-Retinal <-> NADH + H+ + Retinoate
NAD+ + H2O + D-Lactaldehyde <-> NADH + H+ + D-Lactate
NAD+ + H2O + L-Lactaldehyde <-> NADH + H+ + L-Lactate
NAD+ + H2O + 2,5-Dioxopentanoate <-> NADH + H+ + 2-Oxoglutarate
H2O + NADP+ + 2,5-Dioxopentanoate <-> H+ + NADPH + 2-Oxoglutarate
H2O + NADP+ + Butanal <-> H+ + NADPH + Butanoate
H2O + NADP+ + Pentanal <-> H+ + NADPH + Pentanoate
H2O + NADP+ + Hexanal <-> H+ + NADPH + Hexanoate
H2O + NADP+ + Heptanal <-> H+ + NADPH + Heptanoate
H2O + NADP+ + 1-Octanal <-> H+ + NADPH + Octanoate
NAD+ + H2O + 9-cis-Retinal <-> NADH + H+ + Retinoate
NAD+ + H2O + Nonanal <-> NADH + H+ + Nonanoate
NAD+ + H2O + trans-2-Nonenal <-> NADH + H+ + trans-2-Nonenoic acid
2 NAD+ + 4 ALDH <-> Enzyme-ligand complex
2 NAD+ + 2 ALDH <-> Enzyme-ligand complex
2 NADH + 4 ALDH <-> Enzyme-ligand complex
4 NADH + 4 ALDH <-> Enzyme-ligand complex
2 1,N6-etheno-NAD+ + 4 ALDH <-> Enzyme-ligand complex
4 1,N6-etheno-NAD+ + 4 ALDH <-> Enzyme-ligand complex
NAD+ + 1-Propanol <-> NADH + H+ + Propanal
NAD+ + Acetoin <-> NADH + H+ + Dimethylglyoxal
H+ + NADPH + Dimethylglyoxal <-> NADP+ + Acetoin
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.2.1.3



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