Enzyme Details

 EC Classification 1.2.1.5
 Enzyme name
(recommended)
aldehyde dehydrogenase [NAD(P)+]
 Alternative names aldehyde:NAD(P)+ oxidoreductase
aldehyde dehydrogenase [NAD(P)+]
ALDH
 Classification
Oxidoreductases
Acting on the aldehyde or oxo group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
H2O + NADP+ + Acetaldehyde <-> H+ + NADPH + Acetate
NAD+ + H2O + Acetaldehyde <-> NADH + H+ + Acetate
NAD+ + H2O + L-Glutamate 5-semialdehyde <-> NADH + H+ + L-Glutamate
H2O + NADP+ + Aldehyde <-> H+ + NADPH + Acid
NAD+ + H2O + Benzaldehyde <-> NADH + H+ + Benzoate
H2O + NADP+ + Benzaldehyde <-> H+ + NADPH + Benzoate
NAD+ + H2O + 16-Hexadecanal <-> NADH + H+ + Palmitate
NAD+ + H2O + all-trans-Retinal <-> NADH + H+ + Retinoate
NAD+ + H2O + Phenylacetaldehyde <-> NADH + H+ + Phenylacetic acid
H2O + NADP+ + Phenylacetaldehyde <-> H+ + NADPH + Phenylacetic acid
NAD+ + H2O + Indole-3-acetaldehyde <-> NADH + H+ + Indole-3-acetate
NAD+ + H2O + 4-Hydroxyphenylacetaldehyde <-> NADH + H+ + 4-Hydroxyphenylacetate
H2O + NADP+ + 4-Hydroxyphenylacetaldehyde <-> H+ + NADPH + 4-Hydroxyphenylacetate
NAD+ + H2O + 3,4-Dihydroxyphenylacetaldehyde <-> NADH + H+ + 3,4-Dihydroxyphenylacetate
H2O + NADP+ + 3,4-Dihydroxyphenylacetaldehyde <-> H+ + NADPH + 3,4-Dihydroxyphenylacetate
NAD+ + H2O + 3,4-Dihydroxymandelaldehyde <-> NADH + H+ + 3,4-Dihydroxymandelate
H2O + NADP+ + 3,4-Dihydroxymandelaldehyde <-> H+ + NADPH + 3,4-Dihydroxymandelate
NAD+ + H2O + 3-Methoxy-4-hydroxyphenylacetaldehyde <-> NADH + H+ + Homovanillate
H2O + NADP+ + 3-Methoxy-4-hydroxyphenylacetaldehyde <-> H+ + NADPH + Homovanillate
NAD+ + H2O + 3-Methoxy-4-hydroxyphenylglycolaldehyde <-> NADH + H+ + 3-Methoxy-4-hydroxymandelate
H2O + NADP+ + 3-Methoxy-4-hydroxyphenylglycolaldehyde <-> H+ + NADPH + 3-Methoxy-4-hydroxymandelate
NAD+ + H2O + Methylimidazole acetaldehyde <-> NADH + H+ + Methylimidazoleacetic acid
NAD+ + H2O + Butanal <-> NADH + H+ + Butanoate
NAD+ + H2O + 1-Octanal <-> NADH + H+ + Octanoate
NAD+ + H2O + Decanal <-> NADH + H+ + Decanoate
NAD+ + H2O + Hexanal <-> NADH + H+ + Hexanoate
NAD+ + H2O + Heptanal <-> NADH + H+ + Heptanoate
H2O + NADP+ + Propanal <-> H+ + NADPH + Propanoate
NAD+ + H2O + 4-Methoxybenzaldehyde <-> NADH + H+ + 4-Methoxybenzoate
NAD+ + H2O + p-Nitrobenzaldehyde <-> NADH + H+ + p-Nitrobenzoate
NAD+ + H2O + trans-2-Hexenal <-> NADH + H+ + trans-2-Hexenoic acid
H2O + NADP+ + Malondialdehyde <-> H+ + NADPH + 3-Oxopropanoate
H2O + NADP+ + 4-Hydroxy-2-nonenal <-> H+ + NADPH + 4-Hydroxy-2-nonenoic acid
H2O + NADP+ + Dodecanal <-> H+ + NADPH + Dodecanoate
H2O + NADP+ + Decanal <-> H+ + NADPH + Decanoate
H2O + NADP+ + Glyceraldehyde <-> H+ + NADPH + Glycerate
H2O + NADP+ + Nonanal <-> H+ + NADPH + Nonanoate
H2O + NADP+ + trans-2-Hexenal <-> H+ + NADPH + trans-2-Hexenoic acid
H2O + NADP+ + trans-2-Octenal <-> H+ + NADPH + trans-2-Octenoic acid
H2O + NADP+ + trans-2-Nonenal <-> H+ + NADPH + trans-2-Nonenoic acid
H2O + NADP+ + 1-Octanal <-> H+ + NADPH + Octanoate
H2O + NADP+ + Hexanal <-> H+ + NADPH + Hexanoate
NAD+ + H2O + Propanal <-> NADH + H+ + Propanoate
H2O + NADP+ + Pyridine-4-aldehyde <-> H+ + NADPH + Isonicotinic acid
NAD+ + H2O + Aldophosphamide <-> NADH + H+ + 3-[Amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoate
H2O + NADP+ + Aldophosphamide <-> H+ + NADPH + 3-[Amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoate
NAD+ + H2O + Pyridine-4-aldehyde <-> NADH + H+ + Isonicotinic acid
H2O + Propanal + 3-Acetylpyridine-adenine dinucleotide <-> H+ + Propanoate + Reduced 3-acetylpyridine-adenine dinucleotide
H2O + Deamino-NAD+ + Propanal <-> H+ + Propanoate + Deamino-NADH
NAD+ + H2O + Formaldehyde <-> NADH + H+ + Formate
NAD+ + H2O + 2-Methylpropanal <-> NADH + H+ + Isobutanoate
NAD+ + H2O + Glyceraldehyde <-> NADH + H+ + Glycerate
NAD+ + H2O + Glutaral <-> NADH + H+ + 5-Oxopentanoate
NAD+ + H2O + Glycolaldehyde <-> NADH + H+ + Glycolate
NAD+ + H2O + m-Nitrobenzaldehyde <-> NADH + H+ + m-Nitrobenzoate
NAD+ + H2O + 2,4-Dihydroxybenzaldehyde <-> NADH + H+ + 2,4-Dihydroxybenzoate
NAD+ + H2O + Furfural <-> NADH + H+ + 2-Furoate
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


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