Enzyme Details

 EC Classification 1.2.1.88
 Enzyme name
(recommended)
L-glutamate gamma-semialdehyde dehydrogenase
 Alternative names Delta1-pyrroline-5-carboxylate dehydrogenase
1-pyrroline dehydrogenase
pyrroline-5-carboxylate dehydrogenase
pyrroline-5-carboxylic acid dehydrogenase
L-pyrroline-5-carboxylate-NAD+ oxidoreductase
1-pyrroline-5-carboxylate:NAD+ oxidoreductase
Delta1-pyrroline-5-carboxylic acid dehydrogenase
L-glutamate gamma-semialdehyde:NAD+ oxidoreductase
 Classification
Oxidoreductases
Acting on the aldehyde or oxo group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
H2O + NADP+ + Acetaldehyde <-> H+ + NADPH + Acetate
NAD+ + H2O + L-Glutamate 5-semialdehyde <-> NADH + H+ + L-Glutamate
NAD+ + 2 H2O + (S)-1-Pyrroline-5-carboxylate <-> NADH + H+ + L-Glutamate
NAD+ + 2 H2O + L-1-Pyrroline-3-hydroxy-5-carboxylate <-> NADH + H+ + L-erythro-4-Hydroxyglutamate
NAD+ + H2O + Acetaldehyde <-> NADH + H+ + Acetate
2 H2O + NADP+ + (S)-1-Pyrroline-5-carboxylate <-> H+ + L-Glutamate + NADPH
NAD+ + H2O + Succinate semialdehyde <-> NADH + H+ + Succinate
NAD+ + H2O + 3-Oxopropanoate <-> NADH + H+ + Malonate
NAD+ + H2O + 5-Oxopentanoate <-> NADH + H+ + Glutarate
FAD + trans-4-Hydroxy-L-proline <-> FADH2 + L-1-Pyrroline-3-hydroxy-5-carboxylate
2 H2O + NADP+ + L-1-Pyrroline-3-hydroxy-5-carboxylate <-> H+ + NADPH + L-erythro-4-Hydroxyglutamate
NAD+ + L-erythro-4-Hydroxyglutamate <-> NADH + H+ + H2O + L-4-Hydroxyglutamate semialdehyde
NAD+ + H2O + p-Nitrobenzaldehyde <-> NADH + H+ + p-Nitrobenzoate
H2O + p-Nitrophenyl acetate <-> Acetate + p-Nitrophenol
NAD+ + H2O + Propanal <-> NADH + H+ + Propanoate
NAD+ + H2O + 6-Oxohexanoate <-> NADH + H+ + Adipate
NAD+ + H2O + m-Nitrobenzaldehyde <-> NADH + H+ + m-Nitrobenzoate
NAD+ + H2O + Glutamate gamma-semialdehyde <-> NADH + H+ + Glutamate
NAD+ + 2 H2O + 3,4-Dihydro-2H-Pyrrole-2-carboxylate <-> NADH + H+ + L-Glutamate
NAD+ + Delta-1-pyrroline-5-carboxylate dehydrogenase <-> Enzyme-ligand complex
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.2.1.88



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