Enzyme Details

 EC Classification 1.2.4.2
 Enzyme name
(recommended)
oxoglutarate dehydrogenase (succinyl-transferring)
 Alternative names 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)
2-ketoglutarate dehydrogenase
2-oxoglutarate dehydrogenase
2-oxoglutarate: lipoate oxidoreductase
2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating)
alpha-ketoglutarate dehydrogenase
alphaketoglutaric acid dehydrogenase
alpha-ketoglutaric dehydrogenase
alpha-oxoglutarate dehydrogenase
AKGDH
OGDC
ketoglutaric dehydrogenase
oxoglutarate decarboxylase
oxoglutarate dehydrogenase
oxoglutarate dehydrogenase (lipoamide)
 Classification
Oxidoreductases
Acting on the aldehyde or oxo group of donors
With a disulfide as acceptor
 Catalyses reactions
Thiamine diphosphate + 2-Oxoglutarate <-> CO2 + 3-Carboxy-1-hydroxypropyl-ThPP
Lipoamide + 3-Carboxy-1-hydroxypropyl-ThPP <-> Thiamine diphosphate + S-Succinyldihydrolipoamide
Lipoamide + 2-Oxoglutarate <-> CO2 + S-Succinyldihydrolipoamide
NAD+ + Coenzyme A + 2-Oxoadipate <-> NADH + H+ + CO2 + Glutaryl-CoA
Lipoamide + 2-Oxoadipate <-> CO2 + S-Glutaryldihydrolipoamide
NAD+ + Coenzyme A + 2-Oxoglutarate <-> NADH + H+ + CO2 + Succinyl-CoA
H2O + 2-Oxoglutarate + Hexacyanoferrate(III) <-> CO2 + Succinate + Hexacyanoferrate(II)
2-Oxoglutarate + 2,6-Dichloroindophenol <-> CO2 + Succinate semialdehyde + Reduced 2,6-dichlorophenolindophenol
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.2.4.2



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