Enzyme Details

 EC Classification 1.2.4.4
 Enzyme name
(recommended)
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
 Alternative names 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
2-oxoisocaproate dehydrogenase
2-oxoisovalerate (lipoate) dehydrogenase
3-methyl-2-oxobutanoate dehydrogenase (lipoamide)
3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating)
alpha-keto-alpha-methylvalerate dehydrogenase
alpha-ketoisocaproate dehydrogenase
alpha-ketoisocaproic dehydrogenase
alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase
alpha-ketoisovalerate dehydrogenase
alpha-oxoisocaproate dehydrogenase
BCKDH
BCOAD
branched chain keto acid dehydrogenase
branched-chain (-2-oxoacid) dehydrogenase (BCD)
branched-chain 2-keto acid dehydrogenase
branched-chain 2-oxo acid dehydrogenase
branched-chain alpha-keto acid dehydrogenase
branched-chain alpha-oxo acid dehydrogenase
branched-chain keto acid dehydrogenase
branched-chain ketoacid dehydrogenase
dehydrogenase, 2-oxoisovalerate (lipoate)
dehydrogenase, branched chain alpha-keto acid
 Classification
Oxidoreductases
Acting on the aldehyde or oxo group of donors
With a disulfide as acceptor
 Catalyses reactions
NAD+ + Coenzyme A + alpha-Ketovaline <-> NADH + H+ + CO2 + 2-Methylpropanoyl-CoA
Lipoamide + alpha-Ketovaline <-> CO2 + S-(2-Methylpropanoyl)-dihydrolipoamide
Lipoamide + 4-Methyl-2-oxopentanoate <-> CO2 + S-(3-Methylbutanoyl)-dihydrolipoamide
Lipoamide + 3-Methyl-2-oxopentanoate <-> CO2 + S-(2-Methylbutanoyl)-dihydrolipoamide
H2O + alpha-Ketovaline + Acceptor <-> H+ + CO2 + Isobutanoate + Reduced acceptor
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.2.4.4



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