Enzyme Details

 EC Classification 1.8.1.4
 Enzyme name
(recommended)
dihydrolipoyl dehydrogenase
 Alternative names protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
LDP-Glc
LDP-Val
dehydrolipoate dehydrogenase
diaphorase
dihydrolipoamide dehydrogenase
dihydrolipoamide:NAD+ oxidoreductase
dihydrolipoic dehydrogenase
dihydrothioctic dehydrogenase
lipoamide dehydrogenase (NADH)
lipoamide oxidoreductase (NADH)
lipoamide reductase
lipoamide reductase (NADH)
lipoate dehydrogenase
lipoic acid dehydrogenase
lipoyl dehydrogenase
protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase
 Classification
Oxidoreductases
Acting on a sulfur group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NAD+ + Dihydrolipoamide <-> NADH + H+ + Lipoamide
Pyruvate + NAD+ + Coenzyme A <-> NADH + H+ + CO2 + Acetyl-CoA
NADP+ + Dihydrolipoylprotein <-> H+ + NADPH + Lipoylprotein
NADP+ + Dihydrolipoamide <-> H+ + NADPH + Lipoamide
3 NADH + H+ + Cr(VI) <-> 3 NAD+ + Cr(III)
NADH + H+ + Lipoate <-> NAD+ + Dihydrolipoate
NADH + H+ + Nepsilon-Lipoyllysine <-> NAD+ + Nepsilon-Dihydrolipoyllysine
NAD+ + Dihydrolipoylprotein <-> NADH + H+ + Lipoylprotein
NAD+ + N-alpha-(D,L-1,2-dithiolane-3-pentanoyl)-N-[Tris(hydroxymethyl)methyl] glycinamide <-> NADH + H+ + Oxidized N-alpha-(D,L-1,2-dithiolane-3-pentanoyl)-N-[Tris(hydroxymethyl)methyl] glycinamide
NAD+ + N-gamma-(D,L-1,2-dithiolane-3-pentanoyl)-N-[Tris(hydroxymethyl)methyl] butanamide <-> NADH + H+ + Oxidized N-alpha-(D,L-1,2-dithiolane-3-pentanoyl)-N-[Tris(hydroxymethyl)methyl] butanamide
NAD+ + N-gamma-(D-1,2-dithiolane-3-pentanoyl)-N-[Tris(hydroxymethyl)methyl] butanamide <-> NADH + H+ + Oxidized N-alpha-(D-1,2-dithiolane-3-pentanoyl)-N-[Tris(hydroxymethyl)methyl] butanamide
NAD+ + N-alpha-(benzyloxycarbonyl)-N-omega-(D,L-1,2-dithiolane-3-pentanoyl)-L-lysine <-> NADH + H+ + Oxidized N-alpha-(benzyloxycarbonyl)-N-omega-(D,L-1,2-dithiolane-3-pentanoyl)-L-lysine
NADH + H+ + (R)-Lipoic acid <-> NAD+ + (R)-Dihydrolipoic acid
NADH + H+ + (S)-Lipoic acid <-> NAD+ + (S)-Dihydrolipoic acid
NADH + H+ + 1,2-Diselenolane-3-pentanoic acid <-> NAD+ + 6,8-Diselenyloctanoic acid
NADH + H+ + 1,2-Dithiolanecaproic acid <-> NAD+ + 7,9-Dimercaptononanoic acid
NADH + H+ + Bisnorlipoic acid <-> NAD+ + 4,6-Dimercaptohexanoic acid
NADH + H+ + Tetranorlipoic acid <-> NAD+ + 2,4-Dimercaptobutanoic acid
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 1.8.1.4



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