Enzyme Details

 EC Classification 2.3.3.13
 Enzyme name
(recommended)
2-isopropylmalate synthase
 Alternative names acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)
alpha-isopropylmalate synthetase
alpha-isopropylmalate synthase
alpha-isopropylmalic synthetase
isopropylmalate synthase
isopropylmalate synthetase
 Classification
Transferases
Acyltransferases
Acyl groups converted into alkyl on transfer
 Catalyses reactions
H2O + Acetyl-CoA <-> Coenzyme A + Acetate
Coenzyme A + (R)-2-Ethylmalate <-> H2O + Acetyl-CoA + 2-Oxobutyrate
Coenzyme A + 2-Isopropylmalate <-> H2O + Acetyl-CoA + alpha-Ketovaline
H2O + Propanoyl-CoA <-> Coenzyme A + Propanoate
Pyruvate + H2O + Acetyl-CoA <-> Coenzyme A + D-Citramalate
H2O + Crotonoyl-CoA <-> Coenzyme A + 2-Butenoate
H2O + Acetyl-CoA + 2-Oxopentanoate <-> Coenzyme A + 2-Propylmalate
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class 2.3.3.13



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