Pathway Details

 Recommended name Tryptophan metabolism
 Alternative names
 Reactions
L-Tryptophan <-> CO2 + Tryptamine
H2O + 5-Hydroxy-N-formylkynurenine <-> Formate + 5-Hydroxykynurenine
NAD+ + NH3 + 2-Oxoadipate <-> NADH + H+ + H2O + 2-Aminomuconate
NAD+ + Indolelactate <-> NADH + H+ + Indolepyruvate
H2O + Formylkynurenine <-> L-Alanine + Formylanthranilate
H2O + Formylkynurenine <-> Formate + L-Kynurenine
H+ + NADPH + 5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate <-> NADP+ + 5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
2 Acetyl-CoA <-> Coenzyme A + Acetoacetyl-CoA
H2O2 + Nitrite + N-Acetyl-L-tryptophanethylester <-> H2O + Nitro compound
3-Hydroxy-L-kynurenine <-> CO2 + 3-Hydroxykynurenamine
2-Oxobutyrate + Alanine <-> Pyruvate + Aminobutyrate
L-Tryptophan + O2 <-> L-Formylkynurenine
H2O + 3-Hydroxy-L-kynurenine <-> L-Alanine + 3-Hydroxyanthranilate
H+ + NADPH + O2 + 4-Hydroxy-2-quinolinecarboxylic acid <-> NADP+ + 7,8-Dihydro-7,8-dihydroxykynurenate
4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate <-> H2O + 6-Hydroxykynurenate
S-Adenosyl-L-methionine + 5-Hydroxyindoleacetate <-> S-Adenosyl-L-homocysteine + 5-Methoxyindoleacetate
2-Oxobutyrate + Asparagine <-> Aminobutyrate + Ketoacid
H2O + Xanthurenic acid <-> 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
2-Oxoglutarate + 5-Hydroxy-L-tryptophan <-> L-Glutamate + 5-Hydroxyindolepyruvate
H2O + 2-Aminomuconate <-> NH3 + (Z)-5-Oxohex-2-enedioate
H+ + NADPH + O2 + Indolelactate <-> H2O + NADP+ + 6-Hydroxyindolelactate
Indolepyruvate <-> CO2 + Indole-3-acetaldehyde
O2 + 5-Hydroxy-L-tryptophan <-> 5-Hydroxy-N-formylkynurenine
H2O + Glucobrassicin <-> D-Glucose + Sulfate + 3-Indoleacetonitrile + Sulfur
3-Hydroxyanthranilate + Activated methyl group <-> 3-Methoxyanthranilate
O2 + Indole <-> H2O + Indoxyl
2-Oxobutyrate + Serine <-> Aminobutyrate + Ketoacid
NAD+ + Coenzyme A + 2-Oxoadipate <-> NADH + H+ + CO2 + Glutaryl-CoA
O2 + Melatonin <-> Formyl-N-acetyl-5-methoxykynurenamine
5-Hydroxy-L-tryptophan <-> CO2 + Serotonin
H2O + Indole-3-acetamide <-> NH3 + Indole-3-acetate
(S)-3-Hydroxybutanoyl-CoA <-> H2O + Crotonoyl-CoA
CO2 + 5-(2'-Formylethyl)-4,6-dihydroxypicolinate <-> 5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
O2 + 2,3-Dihydroxyindole <-> CO2 + Anthranilate
H2O + Formylanthranilate <-> Formate + Anthranilate
NADP+ + NH3 + 2-Oxoadipate <-> H+ + H2O + NADPH + 2-Aminomuconate
S-Adenosyl-L-methionine + Indolepyruvate <-> S-Adenosyl-L-homocysteine + 3-Methylindolepyruvate
O2 + Serotonin <-> Formyl-5-hydroxykynurenamine
H+ + NADPH + O2 + L-Kynurenine <-> H2O + NADP+ + 3-Hydroxy-L-kynurenine
H2O2 + Nitrite + N-Acetyl-L-tryptophanamide <-> H2O + Nitro compound
2-Oxobutyrate + Tyrosine <-> Aminobutyrate + Ketoacid
N-Acetylisatin <-> O2 + N-Acetylindoxyl
2-Oxoglutarate + 5-Hydroxykynurenine <-> Amino acid + 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
H2O + 2,3-Dihydroxyindole <-> O2 + Indoxyl
ATP + L-Tryptophan + tRNA(Trp) <-> Diphosphate + AMP + L-Tryptophanyl-tRNA(Trp)
L-Tryptophan + 2-Oxoglutarate <-> L-Glutamate + Indolepyruvate
2-Oxobutyrate + Cysteine <-> Aminobutyrate + Ketoacid
2-Oxoglutarate + L-Kynurenine <-> L-Glutamate + 4-(2-Aminophenyl)-2,4-dioxobutanoate
H2O + NADP+ + 5-(2'-Formylethyl)-4,6-dihydroxypicolinate <-> H+ + NADPH + 5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
2 H2O + 3-Indoleacetonitrile <-> NH3 + Indole-3-acetate
O2 + 3-Hydroxykynurenamine <-> NH3 + H2O2 + 4,8-Dihydroxyquinoline
Indole-3-acetaldoxime <-> Glucobrassicin
O2 + Indole-3-acetate <-> 2-Formaminobenzoylacetate
O2 + 7,8-Dihydroxykynurenate <-> 5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
NAD+ + Indole-3-ethanol <-> NADH + H+ + Indole-3-acetaldehyde
NAD+ + H2O + Indole-3-acetaldehyde <-> NADH + H+ + Indole-3-acetate
2-Oxoglutarate + 3-Hydroxy-L-kynurenine <-> L-Glutamate + 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
L-Tryptophan + O2 + Tetrahydrobiopterin <-> H2O + 6,7-Dihydrobiopterin + 5-Hydroxy-L-tryptophan
NAD+ + 7,8-Dihydro-7,8-dihydroxykynurenate <-> NADH + H+ + 7,8-Dihydroxykynurenate
Anthranilate <-> Indole-3-acetaldoxime
NAD+ + H2O + 5-(2'-Formylethyl)-4,6-dihydroxypicolinate <-> NADH + H+ + 5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
Indole-3-acetamide <-> H2O + 3-Indoleacetonitrile
H2O + Pyridine-2,3-dicarboxylate <-> 2-Amino-3-carboxymuconate semialdehyde
Acetyl-CoA + Serotonin <-> Coenzyme A + N-Acetylserotonin
H2O + O2 + Tryptamine <-> NH3 + H2O2 + Indole-3-acetaldehyde
L-Tryptophan + O2 <-> Formylkynurenine
O2 + 3-Hydroxyanthranilate <-> 2-Amino-3-carboxymuconate semialdehyde
2-Amino-3-carboxymuconate semialdehyde <-> CO2 + 2-Aminomuconate semialdehyde
O2 + Indole-3-acetate <-> CO2 + 3-Methyldioxyindole
S-Adenosyl-L-methionine + N-Acetylserotonin <-> S-Adenosyl-L-homocysteine + Melatonin
S-Adenosyl-L-methionine + Tryptamine <-> S-Adenosyl-L-homocysteine + N-Methyltryptamine
H2O + L-Tryptophan + O2 <-> NH3 + H2O2 + Indolepyruvate
H2O + O2 + 5-Hydroxyindoleacetaldehyde <-> O2 + 5-Hydroxyindoleacetate
H2O + L-Formylkynurenine <-> L-Alanine + Formylanthranilate
L-Tryptophan + O2 <-> CO2 + NH3 + 3-Indoleglycolaldehyde
2-Oxobutyrate + Leucine <-> Aminobutyrate + Ketoacid
H2O + beta-Benzoyl-L-alanine <-> L-Alanine + Benzoate
H2O + L-Kynurenine <-> L-Alanine + Anthranilate
2-Oxobutyrate + Histidine <-> Aminobutyrate + Ketoacid
2-Oxobutyrate + Phenylalanine <-> Aminobutyrate + Ketoacid
H2O + O2 + Indole-3-acetaldehyde <-> H2O2 + Indole-3-acetate
2 O2 + 2 3-Hydroxyanthranilate <-> 2 H2O2 + Cinnavalininate
Xanthurenic acid <-> 8-Methoxykynurenate
H2O + O2 + 5-Hydroxykynurenamine <-> H2O + NH3 + H2O2 + 4,6-Dihydroxyquinoline
H2O + L-Tryptophan <-> Pyruvate + NH3 + Indole
NADH + H+ + O2 + 4-Hydroxy-2-quinolinecarboxylic acid <-> NAD+ + 7,8-Dihydro-7,8-dihydroxykynurenate
NH3 + Oxaloacetate + 2-Oxoglutarate <-> 2 O2 + 5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
H2O + O2 + Serotonin <-> NH3 + H2O2 + 5-Hydroxyindoleacetaldehyde
NAD+ + H2O + 2-Aminomuconate semialdehyde <-> NADH + H+ + 2-Aminomuconate
O2 + Indole <-> 2-Formylaminobenzaldehyde
3 O2 + 4 2-Aminophenol <-> 6 H2O + 2 Isophenoxazine
H2O + L-Formylkynurenine <-> Formate + L-Kynurenine
Glutaryl-CoA + Acceptor <-> CO2 + Crotonoyl-CoA + Reduced acceptor
5-Hydroxyindoleacetate <-> 5-Hydroxyindoleacetylglycine
O2 + Reduced flavoprotein + Melatonin <-> H2O + Oxidized flavoprotein + 6-Hydroxymelatonin
2-Oxobutyrate + Tryptophan <-> Aminobutyrate + Ketoacid
NAD+ + H2O + 5-Hydroxyindoleacetaldehyde <-> NADH + H+ + 5-Hydroxyindoleacetate
3-Hydroxyanthranilate <-> CO2 + 2-Aminophenol
S-Adenosyl-L-methionine + Serotonin <-> S-Adenosyl-L-homocysteine + N-Methylserotonin
N-Acetylindoxyl <-> Indoxyl
2-Oxobutyrate + Glutamine <-> Aminobutyrate + Ketoacid
L-Tryptophan + O2 <-> H2O + CO2 + Indole-3-acetamide
Serotonin + Activated methyl group <-> 5-Methoxytryptamine
L-Phenylalanine + O2 + Tetrahydrobiopterin <-> H2O + L-Tyrosine + 6,7-Dihydrobiopterin
Anthranilate <-> 2-Formaminobenzoylacetate
NADP+ + Indole-3-ethanol <-> H+ + NADPH + Indole-3-acetaldehyde
NAD+ + (S)-3-Hydroxybutanoyl-CoA <-> NADH + H+ + Acetoacetyl-CoA
H2O2 + Nitrite + N(alpha)-t-Butoxycarbonyl-L-tryptophanyl-glycineethylester <-> H2O + Nitro compound
O2 + Anthranilate + Tetrahydrobiopterin <-> H2O + 6,7-Dihydrobiopterin + 3-Hydroxyanthranilate
2-Oxobutyrate + Methionine <-> Aminobutyrate + Ketoacid
4-(2-Aminophenyl)-2,4-dioxobutanoate <-> H2O + 4-Hydroxy-2-quinolinecarboxylic acid
3-Indoleacetaldoxime <-> H2O + 3-Indoleacetonitrile
CO2 + 5-Hydroxykynurenamine <-> 5-Hydroxykynurenine
 Classification
Amino Acid Metabolism
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