Pathway Details

 Recommended name Metabolism of xenobiotics by cytochrome P450
 Alternative names
 Reactions
S-(Formylmethyl)glutathione <-> S-(2-Hydroxyethyl)glutathione
Reduced glutathione + Bromobenzene-2,3-oxide <-> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
H+ + NADPH + O2 + Bromobenzene <-> H2O + NADP+ + Bromobenzene-3,4-oxide
H2O + (1S,2R)-Naphthalene 1,2-oxide <-> 1,2-Dihydronaphthalene-1,2-diol
(1R,2S)-Naphthalene 1,2-oxide <-> beta-Naphthol
Reduced glutathione + (1S,2R)-Naphthalene 1,2-oxide <-> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
Bromobenzene-3,4-dihydrodiol <-> 4-Bromocatechol
S-(2-Hydroxyethyl)glutathione <-> S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
Reduced glutathione + (1R,2S)-Naphthalene 1,2-oxide <-> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
NAD+ + H2O + Aldophosphamide <-> NADH + H+ + 3-[Amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoate
Reduced glutathione + 1-Nitronaphthalene-5,6-oxide <-> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
H2O + Bromobenzene-2,3-oxide <-> Bromobenzene-2,3-dihydrodiol
4-Bromophenol-2,3-epoxide <-> 4-Bromocatechol
Bromobenzene-3,4-oxide <-> 4-Bromophenol
Reduced glutathione + Chloroacetyl chloride <-> HCl + S-(2-Chloroacetyl)glutathione
H2O + 2-(S-Glutathionyl)acetyl chloride <-> 2-S-Glutathionyl acetate
NAD+ + H2O + Pyridine-4-aldehyde <-> NADH + H+ + Isonicotinic acid
NAD+ + H2O + Propanal <-> NADH + H+ + Propanoate
NAD+ + H2O + 1-Octanal <-> NADH + H+ + Octanoate
H+ + NADPH + O2 + 1,1-Dichloroethylene <-> H2O + NADP+ + Chloroacetyl chloride
NAD+ + H2O + Acetaldehyde <-> NADH + H+ + Acetate
Naphthalene-1,2-diol <-> 1,2-Naphthoquinone
H+ + NADPH + O2 + Naphthalene <-> H2O + NADP+ + (1S,2R)-Naphthalene 1,2-oxide
NAD+ + Chloral hydrate <-> NADH + H+ + Trichloroacetate
Reduced glutathione + Benzo[a]pyrene-4,5-oxide <-> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
H+ + NADPH + O2 + 1,1-Dichloroethylene <-> H2O + NADP+ + 1,1-Dichloroethylene epoxide
H2O + NADP+ + 1-Octanal <-> H+ + NADPH + Octanoate
Reduced glutathione + 2,2-Dichloroacetaldehyde <-> S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
H+ + NADPH + O2 + 1,1-Dichloroethylene <-> H2O + NADP+ + 2,2-Dichloroacetaldehyde
H+ + NADPH + O2 + Naphthalene <-> H2O + NADP+ + (1R,2S)-Naphthalene 1,2-oxide
NAD+ + H2O + Benzaldehyde <-> NADH + H+ + Benzoate
H+ + NADPH + O2 + 7-Ethoxy-4-trifluoromethylcoumarin <-> Ethanol + NADP+ + 4-(Trifluoromethyl)umbelliferone
H2O + Chloral <-> Chloral hydrate
1-Nitronaphthalene <-> 1-Nitrosonaphthalene
N-Hydroxy-1-aminonaphthalene <-> 1-Naphthylamine
H2O + Glutathione episulfonium ion <-> S-(2-Hydroxyethyl)glutathione
H+ + NADPH + O2 + (-)-Camphor <-> H2O + NADP+ + (-)-exo-5-Hydroxycamphor
1-Nitrosonaphthalene <-> N-Hydroxy-1-aminonaphthalene
NADP+ + 1,2-Dihydronaphthalene-1,2-diol <-> H+ + NADPH + Naphthalene-1,2-diol
S-(Formylmethyl)glutathione <-> Thiodiacetic acid sulfoxide
Reduced glutathione + Bromobenzene-3,4-oxide <-> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
H2O + Chloroacetyl chloride <-> Chloroacetic acid
(1S,2R)-Naphthalene 1,2-oxide <-> alpha-Naphthol
H+ + NADPH + O2 + 1-Nitronaphthalene <-> H2O + NADP+ + 1-Nitronaphthalene-5,6-oxide
Reduced glutathione + 1,1-Dichloroethylene epoxide <-> HCl + 2-(S-Glutathionyl)acetyl chloride
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene <-> (1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2- oxopropanoic acid
(1S,2R)-Naphthalene 1,2-oxide <-> beta-Naphthol
Bromobenzene-2,3-oxide <-> 2-Bromophenol
Dichloroacetyl chloride <-> Dichloroacetate
H+ + NADPH + O2 + Benzpyrene <-> H2O + NADP+ + Benzo[a]pyrene-9,10-oxide
1,4-Dihydroxynaphthalene <-> 1,4-Naphthoquinone
H+ + NADPH + O2 + Trichloroethene <-> H2O + NADP+ + Chloral
H2O + NADP+ + Aldophosphamide <-> H+ + NADPH + 3-[Amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoate
S-(Formylmethyl)glutathione <-> Thiodiacetic acid
H2O + 1-Nitronaphthalene-5,6-oxide <-> 1-Nitro-5,6-dihydroxy-dihydronaphthalene
Reduced glutathione + 1-Nitronaphthalene-7,8-oxide <-> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
4-Bromocatechol <-> 4-Bromo-3,5-cyclohexadiene-1,2-dione
H2O + 2,2-Dichloroacetaldehyde <-> 2,2-Dichloro-1,1-ethanediol
Reduced glutathione + Benzo[a]pyrene-7,8-diol <-> H2O + 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
H2O + 2-(S-Glutathionyl)acetyl glutathione <-> Reduced glutathione + 2-S-Glutathionyl acetate
H+ + NADPH + O2 + Bromobenzene <-> H2O + NADP+ + Bromobenzene-2,3-oxide
H2O + NADP+ + Benzaldehyde <-> H+ + NADPH + Benzoate
H2O + (1R,2S)-Naphthalene 1,2-oxide <-> 1,2-Dihydronaphthalene-1,2-diol
H2O + NADP+ + Acetaldehyde <-> H+ + NADPH + Acetate
H+ + NADPH + O2 + Benzpyrene <-> H2O + NADP+ + Benzo[a]pyrene-7,8-oxide
Glutathione episulfonium ion <-> S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
Reduced glutathione + (1S,2R)-Naphthalene 1,2-oxide <-> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
Reduced glutathione + 1-Nitronaphthalene-5,6-oxide <-> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
Reduced glutathione + 1,2-Dibromoethane <-> 2 Hydrobromic acid + Glutathione episulfonium ion
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene <-> (1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
H+ + NADPH + O2 + 7-Ethoxyresorufin <-> Ethanol + NADP+ + Resorufin
UDPglucuronate + Trichloroethanol <-> UDP + Trichloroethanol glucuronide
Benzo[a]pyrene-9,10-oxide <-> 9-Hydroxybenzo[a]pyrene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene <-> (1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
Reduced glutathione + 2-Bromoacetaldehyde <-> Hydrobromic acid + S-(Formylmethyl)glutathione
H+ + NADPH + O2 + 1,2-Dibromoethane <-> H2O + NADP+ + Hydrobromic acid + 2-Bromoacetaldehyde
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene <-> (1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
H+ + NADPH + O2 + Trichloroethanol <-> H2O + NADP+ + Trichloroacetate
(1R,2S)-Naphthalene 1,2-oxide <-> alpha-Naphthol
H+ + NADPH + O2 + Benzo[a]pyrene-7,8-diol <-> H2O + NADP+ + Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
TCE epoxide <-> Dichloroacetyl chloride
H2O + Bromobenzene-3,4-oxide <-> Bromobenzene-3,4-dihydrodiol
H2O + NADP+ + Pyridine-4-aldehyde <-> H+ + NADPH + Isonicotinic acid
Reduced glutathione + Trichloroethene <-> HCl + S-(1,2-Dichlorovinyl)glutathione
Trichloroacetate <-> Dichloroacetate
H+ + NADPH + O2 + 9-Hydroxybenzo[a]pyrene <-> H2O + NADP+ + 9-Hydroxybenzo[a]pyrene-4,5-oxide
H2O + NADP+ + Propanal <-> H+ + NADPH + Propanoate
H+ + NADPH + O2 + beta-Naphthol <-> H2O + NADP+ + Naphthalene-1,2-diol
Reduced glutathione + 1-Nitronaphthalene-7,8-oxide <-> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
alpha-Naphthol <-> 1,4-Dihydroxynaphthalene
H+ + NADPH + O2 + 4-Bromophenol <-> H2O + NADP+ + 4-Bromophenol-2,3-epoxide
H+ + NADPH + O2 + 1,2-Dihydronaphthalene-1,2-diol <-> H2O + NADP+ + 1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
H+ + NADPH + O2 + 1-Nitronaphthalene <-> H2O + NADP+ + 1-Nitronaphthalene-7,8-oxide
H+ + NADPH + O2 + Trichloroethene <-> H2O + NADP+ + TCE epoxide
H+ + NADPH + O2 + Coumarin <-> H2O + NADP+ + Umbelliferone
H2O + Benzo[a]pyrene-7,8-oxide <-> Benzo[a]pyrene-7,8-diol
Reduced glutathione + 2-(S-Glutathionyl)acetyl chloride <-> HCl + 2-(S-Glutathionyl)acetyl glutathione
H+ + NADPH + O2 + Benzpyrene <-> H2O + NADP+ + Benzo[a]pyrene-4,5-oxide
 Classification
Xenobiotics Biodegradation and Metabolism
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