Pathway Details

 Recommended name Steroid hormone biosynthesis
 Alternative names
 Reactions
3'-Phosphoadenylyl sulfate + 2-Methoxyestradiol-17beta <-> Adenosine 3',5'-bisphosphate + 2-Methoxyestradiol-17beta 3-sulfate
O2 + Reduced ferredoxin + Progesterone <-> H2O + Oxidized ferredoxin + 11beta-Hydroxyprogesterone
NAD+ + 3beta-Hydroxy-5alpha-pregnane-20-one <-> NADH + H+ + 5alpha-Pregnane-3,20-dione
Acceptor + 5beta-Androstane-3,17-dione <-> Reduced acceptor + Androst-4-ene-3,17-dione
UDPglucuronate + 2-Hydroxyestrone <-> UDP + 2-Hydroxyestrone O-glucuronide
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol
O2 + Reduced ferredoxin + 11-Deoxycorticosterone <-> H2O + Oxidized ferredoxin + Corticosterone
NADH + H+ + 16alpha-Hydroxyandrost-4-ene-3,17-dione <-> NAD+ + 16alpha-Hydroxydehydroepiandrosterone
NADP+ + Testosterone <-> H+ + NADPH + Androst-4-ene-3,17-dione
NAD+ + Corticosterone <-> NADH + H+ + 11-Dehydrocorticosterone
NAD+ + Pregnenolone <-> NADH + H+ + Progesterone
19-Hydroxytestosterone <-> 19-Oxotestosterone
O2 + Reduced acceptor + Progesterone <-> H2O + Acceptor + 11alpha-Hydroxyprogesterone
O2 + Ferredoxin + 20alpha,22beta-Dihydroxycholesterol <-> Ferredoxin + 4-Methylpentanal + Pregnenolone
H+ + NADPH + O2 + 22beta-Hydroxycholesterol <-> H2O + NADP+ + 20alpha,22beta-Dihydroxycholesterol
H+ + NADPH + O2 + Cholesterol <-> H2O + NADP+ + 20alpha-Hydroxycholesterol
O2 + Cholesterol + Reduced adrenal ferredoxin <-> H2O + Oxidized adrenal ferredoxin + 4-Methylpentanal + Pregnenolone
NAD+ + 3beta-Hydroxy-5beta-pregnane-20-one <-> NADH + H+ + 5beta-Pregnane-3,20-dione
H+ + NADPH + O2 + Cholesterol <-> H2O + NADP+ + 22beta-Hydroxycholesterol
NAD+ + Cortisol <-> NADH + H+ + Cortisone
NAD+ + Cortolone <-> NADH + H+ + Tetrahydrocortisone
NAD+ + Estradiol-17beta <-> NADH + H+ + Estrone
NADP+ + 20alpha-Hydroxy-4-pregnen-3-one <-> H+ + NADPH + Progesterone
Acceptor + 21-Hydroxy-5beta-pregnane-3,11,20-trione <-> Reduced acceptor + 11-Dehydrocorticosterone
UDPglucuronate + Estradiol-17beta <-> UDP + Estradiol-17beta 3-glucuronide
O2 + Reduced acceptor + Estradiol-17beta <-> H2O + Acceptor + 6beta-Hydroxyestradiol-17beta
NADH + H+ + O2 + Estradiol-17beta <-> NAD+ + H2O + 2-Hydroxyestradiol-17beta
UDPglucuronate + Testosterone <-> UDP + Testosterone glucuronide
NAD+ + 20alpha-Hydroxy-4-pregnen-3-one <-> NADH + H+ + Progesterone
H+ + NADPH + O2 + 20alpha-Hydroxycholesterol <-> H2O + NADP+ + 17alpha,20alpha-Dihydroxycholesterol
NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione
NAD+ + 11beta-Hydroxyandrost-4-ene-3,17-dione <-> NADH + H+ + Adrenosterone
UDPglucuronate + 4-Hydroxyestradiol <-> UDP + 4-Hydroxyestradiol O-glucuronide
NADP+ + 17alpha-Hydroxypregnenolone <-> H+ + NADPH + 17alpha-Hydroxyprogesterone
H+ + NADPH + O2 + 17alpha-Hydroxyprogesterone <-> H2O + NADP+ + 21-Deoxycortisol
H+ + NADPH + O2 + 20alpha-Hydroxycholesterol <-> H2O + NADP+ + 20alpha,22beta-Dihydroxycholesterol
UDPglucuronate + 3alpha-Hydroxy-5beta-androstan-17-one <-> UDP + Etiocholan-3alpha-ol-17-one 3-glucuronide
NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> H+ + NADPH + 5beta-Androstane-3,17-dione
H+ + NADPH + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NADP+ + Tetrahydrocortisone
NADH + H+ + Testosterone <-> NAD+ + Androst-5-ene-3beta,17beta-diol
Acceptor + 5alpha-Androstane-3,17-dione <-> Reduced acceptor + Androst-4-ene-3,17-dione
NADP+ + 3beta-Hydroxyandrost-5-en-17-one <-> H+ + NADPH + Androst-4-ene-3,17-dione
NADP+ + 3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al <-> H+ + NADPH + 11beta,21-Dihydroxy-3,20-oxo-5beta-pregnan-18-al
UDPglucuronate + Nalorphine <-> UDP + Nalorphine O-glucuronide
NADP+ + Estradiol-17beta <-> H+ + NADPH + Estrone
O2 + Reduced acceptor + Progesterone <-> H2O + Acceptor + 17alpha-Hydroxyprogesterone
NAD+ + 21-Hydroxypregnenolone <-> NADH + H+ + 11-Deoxycorticosterone
NADP+ + Estriol <-> H+ + NADPH + 16alpha-Hydroxyestrone
NADH + H+ + O2 + Estrone <-> NAD+ + H2O + 2-Hydroxyestrone
NADP+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione
O2 + Reduced acceptor + Progesterone <-> H2O + Acceptor + 11-Deoxycorticosterone
H+ + NADPH + O2 + Testosterone <-> H2O + NADP+ + 19-Hydroxytestosterone
NADP+ + 5alpha-Pregnane-3,20-dione <-> H+ + NADPH + Progesterone
NAD+ + Cortol <-> NADH + H+ + Urocortisol
UDPglucuronate + Buprenorphine <-> UDP + Buprenorphine O-glucuronide
NADP+ + Corticosterone <-> H+ + NADPH + 11-Dehydrocorticosterone
O2 + Reduced acceptor + 21-Deoxycortisol <-> H2O + Acceptor + Cortisol
H+ + NADPH + Testosterone <-> NADP+ + 4-Androstenediol
H+ + NADPH + O2 + Estradiol-17beta <-> H2O + NADP+ + Estriol
NAD+ + Androst-5-ene-3beta,17beta-diol <-> NADH + H+ + 3beta-Hydroxyandrost-5-en-17-one
Formate + Estradiol-17beta <-> 19-Oxotestosterone
H2O + Estrone 3-sulfate <-> Sulfate + Estrone
S-Adenosyl-L-methionine + 2-Hydroxyestrone <-> S-Adenosyl-L-homocysteine + 2-Methoxyestrone
NAD+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one <-> NADH + H+ + 17alpha-Hydroxyprogesterone
O2 + Reduced acceptor + 11beta-Hydroxyprogesterone <-> H2O + Acceptor + Corticosterone
Acceptor + 5beta-Androstane-17beta-ol-3-one <-> Reduced acceptor + Testosterone
NADP+ + Urocortisol <-> H+ + NADPH + 11beta,17alpha,21-Trihydroxy-5beta-pregnane-3,20-dione
NAD+ + Testosterone <-> NADH + H+ + Androst-4-ene-3,17-dione
NAD+ + Estradiol-17alpha <-> NADH + H+ + Estrone
NAD+ + 3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al <-> NADH + H+ + 11beta,21-Dihydroxy-3,20-oxo-5beta-pregnan-18-al
H+ + NADPH + Cortisol <-> NADP+ + 11beta,17alpha,21-Trihydroxypregnenolone
H+ + NADP+ + 2 Reduced ferredoxin <-> NADPH + 2 Oxidized ferredoxin
Acceptor + 11beta,21-Dihydroxy-5beta-pregnane-3,20-dione <-> Reduced acceptor + Corticosterone
NADP+ + Cortisol <-> H+ + NADPH + Cortisone
NADH + H+ + Cortisol <-> NAD+ + 11beta,17alpha,21-Trihydroxypregnenolone
NAD+ + Pregnanediol <-> NADH + H+ + 3alpha-Hydroxy-5beta-pregnane-20-one
NAD+ + Urocortisol <-> NADH + H+ + 11beta,17alpha,21-Trihydroxy-5beta-pregnane-3,20-dione
NADP+ + 5alpha-Androstane-3alpha-ol-17-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione
Alcohol + 3'-Phosphoadenylyl sulfate + 3beta-Hydroxyandrost-5-en-17-one <-> Adenosine 3',5'-bisphosphate + 3beta-Hydroxyandrost-5-en-17-one 3-sulfate
H+ + NADPH + 16alpha-Hydroxyandrost-4-ene-3,17-dione <-> NADP+ + 16alpha-Hydroxydehydroepiandrosterone
NADH + H+ + 5beta-Androstane-17beta-ol-3-one <-> NAD+ + 5beta-Androstane-3beta,17beta-diol
NADP+ + Tetrahydrocorticosterone <-> H+ + NADPH + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione
NADP+ + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione <-> H+ + NADPH + 21-Hydroxy-5beta-pregnane-3,11,20-trione
3'-Phosphoadenylyl sulfate + 3beta-Hydroxyandrost-5-en-17-one <-> Adenosine 3',5'-bisphosphate + 3beta-Hydroxyandrost-5-en-17-one 3-sulfate
Acceptor + 5beta-Pregnane-3,20-dione <-> Reduced acceptor + Progesterone
O2 + Reduced acceptor + 17alpha-Hydroxyprogesterone <-> H2O + Acceptor + 11-Deoxycortisol
3'-Phosphoadenylyl sulfate + Estrone <-> Adenosine 3',5'-bisphosphate + Estrone 3-sulfate
Acceptor + 11beta,21-Dihydroxy-3,20-oxo-5beta-pregnan-18-al <-> Reduced acceptor + Aldosterone
Androst-4-ene-3,17-dione <-> 7alpha-Hydroxyandrost-4-ene-3,17-dione
Acceptor + 5alpha-Androstane-17beta-ol-3-one <-> Reduced acceptor + Testosterone
NAD+ + Tetrahydrocorticosterone <-> NADH + H+ + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione
NAD+ + 5beta-Androstane-3beta-ol-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione
17alpha-Hydroxyprogesterone <-> Acetaldehyde + Androst-4-ene-3,17-dione
Cortisol <-> 11beta,17alpha,21-Trihydroxy-5beta-pregnane-3,20-dione
H+ + NADPH + O2 + Androst-4-ene-3,17-dione <-> H2O + NADP+ + 19-Hydroxyandrost-4-ene-3,17-dione
NAD+ + Tetrahydrocorticosterone <-> NADH + H+ + 11beta,21-Dihydroxy-5beta-pregnane-3,20-dione
H2O + NADP+ + Formate + Estrone <-> H+ + NADPH + O2 + 19-Oxoandrost-4-ene-3,17-dione
NAD+ + 3beta-Hydroxyandrost-5-en-17-one <-> NADH + H+ + Androst-4-ene-3,17-dione
O2 + Reduced acceptor + Pregnenolone <-> H2O + Acceptor + 17alpha-Hydroxypregnenolone
3'-Phosphoadenylyl sulfate + Estradiol-17beta <-> Adenosine 3',5'-bisphosphate + Estradiol-17beta 3-sulfate
NADP+ + Pregnenolone <-> H+ + NADPH + Progesterone
NADP+ + 11beta-Hydroxyandrost-4-ene-3,17-dione <-> H+ + NADPH + Adrenosterone
UDPglucuronate + Estriol <-> UDP + 16-Glucuronide-estriol
H+ + NADPH + 11-Deoxycortisol <-> NADP+ + 17alpha,21-Dihydroxypregnenolone
NAD+ + 17alpha-Hydroxypregnenolone <-> NADH + H+ + 17alpha-Hydroxyprogesterone
H+ + NADPH + O2 + 17alpha,21-Dihydroxypregnenolone <-> H2O + NADP+ + 11beta,17alpha,21-Trihydroxypregnenolone
O2 + Reduced flavoprotein + Testosterone <-> H2O + Oxidized flavoprotein + 7alpha-Hydroxytestosterone
H2O + Acceptor + 21-Deoxycortisol <-> O2 + Reduced acceptor + 11beta-Hydroxyprogesterone
UDPglucuronate + 2-Methoxyestradiol-17beta <-> UDP + 2-Methoxy-estradiol-17beta 3-glucuronide
H+ + NADPH + O2 + 17alpha,20alpha-Dihydroxycholesterol <-> H2O + NADP+ + 4-Methylpentanal + 17alpha-Hydroxypregnenolone
NAD+ + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione <-> NADH + H+ + 21-Hydroxy-5beta-pregnane-3,11,20-trione
O2 + Reduced adrenal ferredoxin + Corticosterone <-> H2O + Oxidized adrenal ferredoxin + 18-Hydroxycorticosterone
UDPglucuronate + Estrone <-> UDP + Estrone glucuronide
H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + Androstanediol
NADP+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one <-> H+ + NADPH + 17alpha-Hydroxyprogesterone
NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione
Acceptor + 18-Hydroxycorticosterone <-> 2 H+ + Reduced acceptor + Aldosterone
S-Adenosyl-L-methionine + 2-Hydroxyestradiol-17beta <-> S-Adenosyl-L-homocysteine + 2-Methoxyestradiol-17beta
H+ + NADPH + Progesterone <-> NADP+ + 5beta-Pregnane-3,20-dione
NADP+ + 11beta,21-Dihydroxy-3,20-oxo-5beta-pregnan-18-al <-> H+ + NADPH + Aldosterone
NADP+ + Androst-5-ene-3beta,17beta-diol <-> H+ + NADPH + 3beta-Hydroxyandrost-5-en-17-one
O2 + Reduced adrenal ferredoxin + Cholesta-5,7-dien-3beta-ol <-> H2O + Oxidized adrenal ferredoxin + 4-Methylpentanal + 7-Dehydropregnenolone
NADH + H+ + 11-Deoxycortisol <-> NAD+ + 17alpha,21-Dihydroxypregnenolone
UDPglucuronate + 4-Hydroxyestrone <-> UDP + 4-Hydroxyestrone O-glucuronide
H2O + 3beta-Hydroxyandrost-5-en-17-one 3-sulfate <-> Sulfate + 3beta-Hydroxyandrost-5-en-17-one
H+ + NADPH + O2 + Estradiol-17beta <-> H2O + NADP+ + 2-Hydroxyestradiol-17beta
O2 + Reduced acceptor + Pregnenolone <-> H2O + Acceptor + 21-Hydroxypregnenolone
NADP+ + Tetrahydrocorticosterone <-> H+ + NADPH + 11beta,21-Dihydroxy-5beta-pregnane-3,20-dione
NADP+ + 11beta,17alpha,21-Trihydroxy-5beta-pregnane-3,20-dione <-> H+ + NADPH + Cortisol
H2O + NADP+ + Acetate + 3beta-Hydroxyandrost-5-en-17-one <-> H+ + NADPH + O2 + 17alpha-Hydroxypregnenolone
O2 + Reduced adrenal ferredoxin + Androst-4-ene-3,17-dione <-> H2O + Oxidized adrenal ferredoxin + 11beta-Hydroxyandrost-4-ene-3,17-dione
O2 + Reduced acceptor + Androst-4-ene-3,17-dione <-> H2O + Acceptor + 3-Oxo-13,17-secoandrost-4-ene-17,13alpha-lactone
UDPglucuronate + 5alpha-Androstane-3alpha-ol-17-one <-> UDP + Androsterone glucuronide
NADP+ + Estradiol-17alpha <-> H+ + NADPH + Estrone
NAD+ + Estriol <-> NADH + H+ + 16alpha-Hydroxyestrone
NAD+ + 3alpha,20alpha,21-Trihydroxy-5beta-pregnane-11-one <-> NADH + H+ + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione
UDPglucuronate + 2-Hydroxyestradiol <-> UDP + 2-Hydroxyestradiol O-glucuronide
O2 + Reduced ferredoxin + 11-Deoxycortisol <-> H2O + Oxidized ferredoxin + Cortisol
Acceptor + 7alpha-Hydroxytestosterone <-> Reduced acceptor + 7alpha-Hydroxyandrost-4-ene-3,17-dione
H+ + NADPH + O2 + Estrone <-> H2O + NADP+ + 16alpha-Hydroxyestrone
H+ + NADPH + 19-Hydroxyandrost-4-ene-3,17-dione <-> NADP+ + 19-Oxoandrost-4-ene-3,17-dione
NADP+ + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> H+ + NADPH + Cortisone
H+ + NADPH + O2 + 3beta-Hydroxyandrost-5-en-17-one <-> H2O + NADP+ + 16alpha-Hydroxydehydroepiandrosterone
H+ + NADPH + O2 + 17alpha-Hydroxypregnenolone <-> H2O + NADP+ + 17alpha,21-Dihydroxypregnenolone
H+ + NADPH + O2 + Estrone <-> H2O + NADP+ + 2-Hydroxyestrone
3'-Phosphoadenylyl sulfate + 2-Methoxyestrone <-> Adenosine 3',5'-bisphosphate + 2-Methoxyestrone 3-sulfate
NADP+ + 21-Hydroxypregnenolone <-> H+ + NADPH + 11-Deoxycorticosterone
NADH + H+ + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> NAD+ + Tetrahydrocortisone
NAD+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> NADH + H+ + 5beta-Pregnane-3,20-dione
UDPglucuronate + 2-Methoxyestrone <-> UDP + 2-Methoxyestrone 3-glucuronide
 Classification
Lipid Metabolism
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