Pathway Details

 Recommended name Lysine biosynthesis
 Alternative names
 Reactions
2-Oxoglutarate + N6-Acetyl-LL-2,6-diaminoheptanedioate <-> L-Glutamate + N-Acetyl-L-2-amino-6-oxopimelate
H2O + N-Succinyl-LL-2,6-diaminoheptanedioate <-> Succinate + LL-2,6-Diaminoheptanedioate
NADP+ + 2,3,4,5-Tetrahydrodipicolinate <-> H+ + NADPH + L-2,3-Dihydrodipicolinate
L-2-Amino-6-oxoheptanedioate <-> H2O + 2,3,4,5-Tetrahydrodipicolinate
2-Oxoglutarate + N-Succinyl-LL-2,6-diaminoheptanedioate <-> L-Glutamate + N-Succinyl-2-L-amino-6-oxoheptanedioate
H2O + NADP+ + meso-2,6-Diaminoheptanedioate <-> H+ + NADPH + NH3 + L-2-Amino-6-oxoheptanedioate
Homoisocitrate <-> H2O + But-1-ene-1,2,4-tricarboxylate
NAD+ + H2O + N6-(L-1,3-Dicarboxypropyl)-L-lysine <-> NADH + H+ + L-Lysine + 2-Oxoglutarate
2-Oxoglutarate + L-2-Aminoadipate <-> L-Glutamate + 2-Oxoadipate
Coenzyme A + Homocitrate <-> H2O + Acetyl-CoA + 2-Oxoglutarate
Pyruvate + L-Aspartate 4-semialdehyde <-> 2 H2O + L-2,3-Dihydrodipicolinate
L-2-Aminoadipate adenylate + Holo-Lys2 <-> AMP + alpha-Aminoadipoyl-S-acyl enzyme
NAD+ + L-Homoserine <-> NADH + H+ + L-Aspartate 4-semialdehyde
H2O + Acetyl-CoA + 2,3,4,5-Tetrahydrodipicolinate <-> Coenzyme A + N-Acetyl-L-2-amino-6-oxopimelate
ATP + D-Alanyl-D-alanine + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6- diaminopimelate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl- D-alanine
Phosphate + NADP+ + L-Aspartate 4-semialdehyde <-> H+ + NADPH + 4-Phospho-L-aspartate
NAD+ + Homoisocitrate <-> NADH + H+ + CO2 + 2-Oxoadipate
H2O + N6-Acetyl-LL-2,6-diaminoheptanedioate <-> Acetate + LL-2,6-Diaminoheptanedioate
NAD+ + 2,3,4,5-Tetrahydrodipicolinate <-> NADH + H+ + L-2,3-Dihydrodipicolinate
NADP+ + L-Homoserine <-> H+ + NADPH + L-Aspartate 4-semialdehyde
ATP + meso-2,6-Diaminoheptanedioate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6- diaminopimelate
H2O + Succinyl-CoA + 2,3,4,5-Tetrahydrodipicolinate <-> Coenzyme A + N-Succinyl-2-L-amino-6-oxoheptanedioate
Homocitrate <-> H2O + But-1-ene-1,2,4-tricarboxylate
ATP + L-2-Aminoadipate <-> Diphosphate + L-2-Aminoadipate adenylate
meso-2,6-Diaminoheptanedioate <-> L-Lysine + CO2
LL-2,6-Diaminoheptanedioate <-> meso-2,6-Diaminoheptanedioate
H2O + NADP+ + N6-(L-1,3-Dicarboxypropyl)-L-lysine <-> H+ + L-Glutamate + NADPH + L-2-Aminoadipate 6-semialdehyde
ATP + L-Aspartate <-> ADP + 4-Phospho-L-aspartate
 Classification
Amino Acid Metabolism
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