Pathway Details

 Recommended name Lysine degradation
 Alternative names
 Reactions
L-Lysine + 2-Oxoglutarate <-> L-Glutamate + L-2-Aminoadipate 6-semialdehyde
O2 + 2-Oxoglutarate + N6,N6,N6-Trimethyl-L-lysine <-> CO2 + Succinate + 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
2 Acetyl-CoA <-> Coenzyme A + Acetoacetyl-CoA
2-Oxoglutarate + N-Succinyl-LL-2,6-diaminoheptanedioate <-> L-Glutamate + N-Succinyl-2-L-amino-6-oxoheptanedioate
NAD+ + H2O + (3S,5S)-3,5-Diaminohexanoate <-> NADH + H+ + NH3 + (S)-5-Amino-3-oxohexanoate
2-Oxoglutarate + L-2-Aminoadipate <-> L-Glutamate + 2-Oxoadipate
L-2-Aminoadipate <-> N2-Acetyl-L-aminoadipate
ATP + D-Alanyl-D-alanine + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6- diaminopimelate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl- D-alanine
NADP+ + L-Homoserine <-> H+ + NADPH + L-Aspartate 4-semialdehyde
Acetyl-CoA + 2,3,4,5-Tetrahydrodipicolinate <-> Coenzyme A + N-Acetyl-L-2-amino-6-oxopimelate
ATP + Coenzyme A + Glutarate <-> ADP + Phosphate + Glutaryl-CoA
Cadaverine <-> Piperideine
O2 + L-Pipecolate <-> H2O2 + 2,3,4,5-Tetrahydropyridine-2-carboxylate
ATP + L-2-Aminoadipate <-> Diphosphate + L-2-Aminoadipate adenylate
H2O + 5-Acetamidopentanoate <-> Acetate + 5-Aminopentanoate
UDPgalactose + 5-Hydroxy-L-lysine <-> UDP + Procollagen 5-(D-galactosyloxy)-L-lysine
H2O + NADP+ + N2-(D-1-Carboxyethyl)-L-lysine <-> Pyruvate + H+ + L-Lysine + NADPH
Protein + N6,N6,N6-Trimethyl-L-lysine <-> H2O + Protein N6,N6,N6-trimethyl-L-lysine
NAD+ + H2O + N6-(L-1,3-Dicarboxypropyl)-L-lysine <-> NADH + H+ + L-Lysine + 2-Oxoglutarate
(S)-3-Hydroxybutanoyl-CoA <-> H2O + Crotonoyl-CoA
NADP+ + L-Pipecolate <-> H+ + NADPH + delta1-Piperideine-2-carboxylate
NADH + H+ + CO2 + 5-Acetamidopentanoate <-> NAD+ + H2O + 6-Acetamido-2-oxohexanoate
2-Oxoglutarate + N6-Acetyl-LL-2,6-diaminoheptanedioate <-> L-Glutamate + N-Acetyl-L-2-amino-6-oxopimelate
NAD+ + Homoisocitrate <-> NADH + H+ + Oxaloglutarate
FAD + L-Pipecolate <-> FADH2 + 2,3,4,5-Tetrahydropyridine-2-carboxylate
H+ + NADPH + N2-Acetyl-L-aminoadipyl-delta-phosphate <-> Phosphate + NADP+ + N2-Acetyl-L-aminoadipate semialdehyde
Dihydrolipoamide + Glutaryl-CoA <-> Coenzyme A + S-Glutaryldihydrolipoamide
ATP + N2-Acetyl-L-aminoadipate <-> ADP + N2-Acetyl-L-aminoadipyl-delta-phosphate
H+ + NADPH + alpha-Aminoadipoyl-S-acyl enzyme <-> NADP+ + L-2-Aminoadipate 6-semialdehyde + Holo-Lys2
Acetyl-CoA + N6-Hydroxy-L-lysine <-> Coenzyme A + N6-Acetyl-N6-hydroxy-L-lysine
H2O + 5-Aminopentanamide <-> NH3 + 5-Aminopentanoate
L-Lysine + Acetyl phosphate <-> Phosphate + N6-Acetyl-L-lysine
H2O + NADP+ + meso-2,6-Diaminoheptanedioate <-> H+ + NADPH + NH3 + L-2-Amino-6-oxoheptanedioate
L-Lysine <-> CO2 + Cadaverine
NAD+ + H2O + 5-Oxopentanoate <-> NADH + H+ + Glutarate
S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <-> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine
H2O + 6-Acetamido-2-oxohexanoate <-> Acetate + 6-Amino-2-oxohexanoate
Phosphate + NADP+ + L-Aspartate 4-semialdehyde <-> H+ + NADPH + 4-Phospho-L-aspartate
NAD+ + H2O + 4-Trimethylammoniobutanal <-> NADH + H+ + 4-Trimethylammoniobutanoate
L-Lysine + O2 <-> H2O + CO2 + 5-Aminopentanamide
2-Oxoglutarate + 5-Aminopentanoate <-> L-Glutamate + 5-Oxopentanoate
H2O + N6-Acetyl-LL-2,6-diaminoheptanedioate <-> Acetate + LL-2,6-Diaminoheptanedioate
NAD+ + 2,3,4,5-Tetrahydrodipicolinate <-> NADH + H+ + L-2,3-Dihydrodipicolinate
H2O + NADP+ + 2,5-Diaminohexanoate <-> H+ + NADPH + NH3 + 2-Amino-5-oxohexanoate
S-Adenosyl-L-methionine + Protein lysine <-> S-Adenosyl-L-homocysteine + Protein N6-methyl-L-lysine
ATP + L-Lysine + tRNA(Lys) <-> Diphosphate + AMP + L-Lysyl-tRNA(Lys)
Oxaloglutarate <-> CO2 + 2-Oxoadipate
H2O + NADP+ + N6-(L-1,3-Dicarboxypropyl)-L-lysine <-> H+ + L-Glutamate + NADPH + L-2-Aminoadipate 6-semialdehyde
NAD+ + H2O + 2,5-Diaminohexanoate <-> NADH + H+ + NH3 + 2-Amino-5-oxohexanoate
O2 + 2-Oxoglutarate + N6,N6,N6-Trimethyl-L-lysine <-> H2O + CO2 + Succinate + 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
NAD+ + H2O + N6-(L-1,3-Dicarboxypropyl)-L-lysine <-> NADH + H+ + L-Glutamate + L-2-Aminoadipate 6-semialdehyde
L-2-Aminoadipate adenylate + Holo-Lys2 <-> AMP + alpha-Aminoadipoyl-S-acyl enzyme
3-Dehydroxycarnitine <-> Carnitine
H2O + L-Lysine + O2 <-> NH3 + H2O2 + 6-Amino-2-oxohexanoate
S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <-> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
2-Oxoglutarate + N6-Acetyl-L-lysine <-> L-Glutamate + 6-Acetamido-2-oxohexanoate
NAD+ + L-Pipecolate <-> NADH + H+ + delta1-Piperideine-2-carboxylate
D-Lysine <-> 2,5-Diaminohexanoate
L-Lysine <-> D-Lysine
ATP + meso-2,6-Diaminoheptanedioate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6- diaminopimelate
H2O + Succinyl-CoA + 2,3,4,5-Tetrahydrodipicolinate <-> Coenzyme A + N-Succinyl-2-L-amino-6-oxoheptanedioate
NAD+ + H2O + L-2-Aminoadipate 6-semialdehyde <-> NADH + H+ + L-2-Aminoadipate
meso-2,6-Diaminoheptanedioate <-> L-Lysine + CO2
H2O + 2,3,4,5-Tetrahydropyridine-2-carboxylate <-> L-2-Aminoadipate 6-semialdehyde
Pyruvate + L-Aspartate 4-semialdehyde <-> 2 H2O + L-2,3-Dihydrodipicolinate
4 ATP + Citrate + N6-Acetyl-N6-hydroxy-L-lysine <-> 4 ADP + 4 Phosphate + Aerobactin
O2 + delta1-Piperideine-2-carboxylate <-> H2O2 + Picolinic acid
L-Lysine + Acetyl-CoA <-> Coenzyme A + N6-Acetyl-L-lysine
O2 + 2-Oxoglutarate + 4-Trimethylammoniobutanoate <-> CO2 + L-Carnitine + Succinate
2-Oxoglutarate + D-Lysine <-> D-Amino acid + 6-Amino-2-oxohexanoate
O2 + 2-Oxoglutarate + Protein lysine <-> H2O + CO2 + Succinate + 5-Hydroxy-L-lysine
6-Amino-2-oxohexanoate <-> H2O + delta1-Piperideine-2-carboxylate
NADP+ + 2,3,4,5-Tetrahydrodipicolinate <-> H+ + NADPH + L-2,3-Dihydrodipicolinate
H+ + L-Lysine + NADPH + O2 <-> H2O + NADP+ + N6-Hydroxy-L-lysine
O2 + 4-Trimethylammoniobutanoate + 3-Bromo-2-ketoglutarate <-> CO2 + L-Carnitine + 3-Bromo-succinate
L-2-Amino-6-oxoheptanedioate <-> H2O + 2,3,4,5-Tetrahydrodipicolinate
Glutaryl-CoA + Acceptor <-> CO2 + Crotonoyl-CoA + Reduced acceptor
Lipoamide + 2-Oxoadipate <-> CO2 + S-Glutaryldihydrolipoamide
UDP-D-galactose + 5-Hydroxy-L-lysine <-> UDP + Procollagen 5-(D-galactosyl)-L-lysine
L-beta-Lysine <-> (3S,5S)-3,5-Diaminohexanoate
H2O + NADP+ + L-2-Aminoadipate 6-semialdehyde <-> H+ + NADPH + L-2-Aminoadipate
NAD+ + L-Homoserine <-> NADH + H+ + L-Aspartate 4-semialdehyde
H2O + N2-Acetyl-L-lysine <-> L-Lysine + Acetate
L-Lysine <-> L-beta-Lysine
H2O + N6-Acetyl-L-lysine <-> L-Lysine + Acetate
LL-2,6-Diaminoheptanedioate <-> meso-2,6-Diaminoheptanedioate
GTP + 5-Hydroxy-L-lysine <-> GDP + 5-Phosphonooxy-L-lysine
H2O + NADP+ + N6-(L-1,3-Dicarboxypropyl)-L-lysine <-> H+ + L-Lysine + NADPH + 2-Oxoglutarate
NAD+ + (S)-3-Hydroxybutanoyl-CoA <-> NADH + H+ + Acetoacetyl-CoA
O2 + 2-Oxoglutarate + 4-Trimethylammoniobutanoate <-> CO2 + Succinate + Carnitine
Glycine + 4-Trimethylammoniobutanal <-> 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
L-Glutamate + N2-Acetyl-L-aminoadipate semialdehyde <-> 2-Oxoglutarate + N2-Acetyl-L-lysine
 Classification
Amino Acid Metabolism
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