Reaction Details



 Reaction ID 523
 Stochiometric Equation Pyruvate + NAD+ + Coenzyme A <-> NADH + H+ + CO2 + Acetyl-CoA
 Substrates
NAD+
Pyruvate
Coenzyme A
 Products
CO2
Acetyl-CoA
H+
NADH
 Enzymes known to
 catalyse this reaction
 (curated information)
EC Number in Organism UniProtKB Link PubMedID
1.2.4.1 Escherichia coli UniProtKB 12751797
1.2.4.1 Escherichia coli UniProtKB 16027371
1.2.4.1 Homo sapiens UniProtKB 8548923
1.2.4.1 Mycobacterium bovis UniProtKB 16027371
1.2.4.1 Mycobacterium smegmatis UniProtKB 16027371
1.2.4.1 Mycobacterium tuberculosis UniProtKB 16027371
1.2.4.1 Pisum sativum UniProtKB 16667685
1.2.4.1 Scheffersomyces stipitis UniProtKB 8669897
1.2.4.1 Solanum tuberosum UniProtKB 16667685
Complex: 1.2.4.1 / 2.3.1.12 / 1.8.1.4 Corynebacterium glutamicum UniProtKB 20675489
Complex: 1.2.4.1 / 2.3.1.12 / 1.8.1.4 Enterococcus faecalis UniProtKB 1730230
Complex: 1.2.4.1 / 2.3.1.12 / 1.8.1.4 Escherichia coli UniProtKB 11583990
Complex: 1.2.4.1 / 2.3.1.12 / 1.8.1.4 Escherichia coli UniProtKB 8969175
Complex: 1.2.4.1 / 2.3.1.12 / 1.8.1.4 Homo sapiens UniProtKB 11485553
Complex: 1.2.4.1 / 2.3.1.12 / 1.8.1.4 Homo sapiens UniProtKB 2087902
Complex: 1.2.4.1 / 2.3.1.12 / 1.8.1.4 Lactococcus lactis subsp. lactis UniProtKB 1624471
Complex: 1.2.4.1 / 2.3.1.12 / 1.8.1.4 Solanum tuberosum UniProtKB 9729464
Complex: 1.2.4.2 / 2.3.1.61 / 1.8.1.4 Azotobacter vinelandii UniProtKB 10848975
Complex: 1.2.4.4 / 2.3.1.168 Bos taurus UniProtKB 283398
Complex: 1.2.4.4 / 2.3.1.168 Oryctolagus cuniculus UniProtKB 7142221
Complex: 1.2.4.4 / 2.3.1.168 / 1.8.1.4 Homo sapiens UniProtKB 3593587
Complex: 1.2.4.4 / 2.3.1.168 / 1.8.1.4 Rattus norvegicus UniProtKB 3571202
 Pathways Glycolysis/Gluconeogenesis
Pyruvate metabolism
 External Links
 KEGG-Pathway-ID map00010
map620
 KEGG-Reaction-ID R00209
 MetaNetX-Reaction-ID MNXR102425
 Rhea-Reaction-ID 28043 28042 28045 28044
 Reactome-Reaction-ID R-SCE-71397 R-GGA-373177 R-CFA-71397 R-RNO-71397 R-DME-71397 R-HSA-71397 R-SSC-71397 R-DRE-71397 R-TGU-71397 R-MMU-71397 R-SPO-71397 R-OSA-71397 R-XTR-71397 R-BTA-71397 R-CEL-71397 R-ATH-71397 R-DDI-71397 R-GGA-71397
 MetaCyc-Reaction-ID PYRUVDEH-RXN


View all entries for reaction Pyruvate + NAD+ + Coenzyme A <-> NADH + H+ + CO2 + Acetyl-CoA

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